Author

Yan Dong

University of CambridgeORCID 0009-0002-4376-0459Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:C. elegans· 3 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:ATAC-seq· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Julie AhringeriD· 3 shared Alex Appert· 2 shared Francesco Nicola CarelliiD· 2 shared Anna F. Townley· 1 shared Anna Victoria ProtasioiD· 1 shared Beibei Zhao· 1 shared Chao PengiD· 1 shared Chiara Cerrato· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersGenomics

Julie AhringerORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Innate immune stress pathway activation underlies heterochromatin dysfunction pathology

Roopali Pradhan, Anna F. Townley, Anna Victoria Protasio, Joshua Miguel C. Danac, Yan Dong, Yushan Fang, Alex Appert, Francesco Nicola Carelli, Shixun Han, Heli Vaikkinen, Iva A. Tchasovnikarova, Julie Ahringer

The paper identifies activation of the innate immune stress pathway as a mechanism linking heterochromatin dysfunction to pathological phenotypes in C. elegans and human cells.

bioRxiv · Sep 26, 2026 · PreprintGenetics

Asymmetric binding of coactivator SRC1 to FXR-RXR and allosteric communication within the complex

Yanan Sheng, Yaoting Guo, Beibei Zhao, Sun Mingze, Yan Dong, Yue Yin, Yanwu Wang, Chao Peng, Yong Xu, Na Wang, Jinsong Liu

This study reveals the asymmetric binding of SRC1 to FXR-RXR and the allosteric communication within the complex, providing a structural model for understanding FXR function and its disease implications.

Communications Biology · Mar 13, 2025Peer-reviewedBiophysics

A lineage-resolved multimodal single-cell atlas reveals the genomic dynamics of early C. elegans development

Servaas N. van der Burght, Francesco Nicola Carelli, Alex Appert, Yan Dong, Matthew Hill, Toby Buttress, Richard Butler, Julie Ahringer

This study constructs a lineage-resolved single-cell multimodal atlas of early C. elegans development, revealing genomic dynamics and zygotic genome activation mechanisms.

bioRxiv · Dec 2, 2024 · PreprintGenomics

Tissue-specific profiling reveals distinctive regulatory architectures for ubiquitous, germline and somatic genes

Jacques Serizay, Yan Dong, Jürgen Jänes, Michael A. Chesney, Chiara Cerrato, Julie Ahringer

The paper identifies distinct regulatory architectures for ubiquitous, germline, and somatic genes in C. elegans by analyzing promoter features across five tissues.

Genome Research · Dec 1, 2020Peer-reviewedGenomics