Author

Cornelis Hendrik Hokke

Leiden UniversityORCID 0000-0003-3545-7804Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Bart EvertsiD· 2 shared Karl F. HoffmanniD· 2 shared Meta RoestenbergiD· 2 shared Paul J. BrindleyiD· 2 shared Shannon E. KarinshakiD· 2 shared Victoria H. ManniD· 2 shared Wannaporn IttiprasertiD· 2 shared Alan TraceyiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

Bart EvertsORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

O-GlcNAcylation and low glycolysis underpin Th2 polarization by dendritic cells

Leonard R. Pelgrom, Marjolein Quik, José Javier Fernández, Thiago A. Patente, Graham A. Heieis, Alexey Sergushichev, Jie Kang, Xiaobo Wang, Justine Dontaine, Marie-Sophie Fabre, Frank Otto, Alwin J. van der Ham, Lisa W. Bloemberg, Marion H. König, Béatrice M. F. Winkel, , Bart Everts

This study identifies O-GlcNAcylation and reduced glycolysis as key factors in Th2 polarization by dendritic cells, showing their role in immune synapse regulation and TCR signaling.

bioRxiv · Feb 5, 2026 · PreprintImmunology

Pre-clinical studies of Schistosoma mansoni vaccines: a scoping review

Emma L. Houlder, Lucas Ferreira da Silva, Angela van Diepen, Murilo Sena Amaral, Robert Alan Wilson, Cornelis Hendrik Hokke, Meta Roestenberg, Wilfried A.M. Bakker

This paper reviews pre-clinical Schistosoma mansoni vaccine studies, finding that only two antigens achieved over 90% efficacy, but most vaccines fall short of required thresholds due to variable formulations and study designs.

PLoS neglected tropical diseases · Jun 2, 2025Peer-reviewedImmunology

Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production

Benjamin J. Hulme, Kathrin K. Geyer, Josephine Forde-Thomas, Gilda Padalino, Dylan Wyn Phillips, Wannaporn Ittiprasert, Shannon E. Karinshak, Victoria H. Mann, Iain W. Chalmers, Paul J. Brindley, Cornelis Hendrik Hokke, Karl F. Hoffmann

This paper identifies and characterizes SmNAGAL, a glycosyl hydrolase in Schistosoma mansoni, showing its role in coordinating parasite movement and egg production, suggesting it as a potential target for new anthelmintic drugs.

PLoS Pathogens · Jan 13, 2022Peer-reviewedMolecular Biology

Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni

Wannaporn Ittiprasert, Victoria H. Mann, Shannon E. Karinshak, Avril Coghlan, Gabriel Rinaldi, Geetha Sankaranarayanan, Apisit Chaidee, Toshihiko Tanno, Chutima Kumkhaek, Pannathee Prangtaworn, Margaret M. Mentink‐Kane, Christina J. Cochran, Patrick Driguez, Nancy E. Holroyd, Alan Tracey, , Paul J. Brindley

This paper demonstrates CRISPR/Cas9-based genome editing in Schistosoma mansoni, successfully mutating the omega-1 gene and reducing Th2 cytokine responses and granuloma formation.

eLife · Jan 14, 2019Peer-reviewedMolecular Biology