Author

Yukari Isayama

Institute of Science Tokyo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Kazuki KatoiD· 2 shared A. Maeda· 1 shared Akiko Shimazaki-Takahashi· 1 shared Antonella NotarnicolaiD· 1 shared Begum HoruluogluiD· 1 shared Caroline GrönwalliD· 1 shared Celia Torres-AranciviaiD· 1 shared Cian Schmitt-UlmsiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

Kazuki KatoORCID

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2 papers

Recent·Most cited

MDA5 multimerization on LINE RNA drives pathogenic extracellular immune complexes in autoimmunity

T. Hsu, Xi Wang, Jiayan Zhang, Yukari Isayama, Viktoria E. M. Schindler, Eveline Van Gompel, Hadil Maadadi, Celia Torres-Arancivia, Akiko Shimazaki-Takahashi, Nina Kurihara, Mariko Kondo, Marina Galesic, Antonella Notarnicola, Sharmin Sultana, A. Maeda, , Sun Hur

Patient-derived anti-MDA5 antibodies bind MDA5 filaments in two germline-encoded modes; only filament immune complexes activate innate immunity, with LINE-derived dsRNA scaffolding circulating filaments in patient plasma.

bioRxiv · Jul 31, 2026 · PreprintBiochemistry✦ In-depth digest

RNA-triggered protein cleavage and cell death by the RNA-guided type III-E CRISPR-Cas nuclease-protease complex

Kazuki Kato, Sae Okazaki, Cian Schmitt-Ulms, Kaiyi Jiang, Wenyuan Zhou, Junichiro Ishikawa, Yukari Isayama, Shungo Adachi, Tomohiro Nishizawa, Kira S. Makarova, Eugene V. Koonin, Omar O. Abudayyeh, Jonathan S. Gootenberg, Hiroshi Nishimasu

This study characterizes the RNA-guided nuclease-protease complex Cas7-11-Csx29, showing target RNA binding activates Csx29 to cleave Csx30, leading to cell death.

bioRxiv · Aug 17, 2022 · PreprintMolecular Biology