Vincent Mooser

Phenome-wide Mendelian randomization identifying circulating proteins for cardiovascular traits in populations of African ancestry

This study uses Mendelian randomization to identify circulating proteins associated with cardiovascular traits in African-ancestry populations and finds four proteins uniquely linked to lipids and heart diseases in this group.

Multi-ancestry proteogenomic analysis identifies risk proteins for intracranial aneurysms

This paper identifies risk proteins for intracranial aneurysms using multi-ancestry proteogenomic analysis and finds ADH4 and PLEKHA1 as non-blood pressure-mediated candidates.

Disentangling osteoarthritis-specific genetic effects from obesity to identify novel therapeutic targets

This study identifies OA-specific genetic effects and novel therapeutic targets by separating OA genetics from those shared with obesity using GWAS and proteomics data.

Frequency enrichment of coding variants in a French-Canadian founder population and its implication for inflammatory bowel diseases

The paper identifies enriched coding variants in a French-Canadian founder population and explores their association with inflammatory bowel diseases.

Genome-wide Association Study of Long COVID

This study performs a genome-wide association study for Long COVID, identifying a significant association with the FOXP4 locus and highlighting the role of pulmonary dysfunction and COVID-19 severity.

Multi-ancestry proteome-phenome-wide Mendelian randomization offers a comprehensive protein-disease atlas and potential therapeutic targets

This study uses proteome-phenome-wide Mendelian randomization across three ancestries to identify protein-phenotype associations and potential therapeutic targets.

WEGS: a cost-effective sequencing method for genetic studies combining high-depth whole exome and low-depth whole genome

WEGS combines low-depth whole genome and high-depth whole exome sequencing to reduce costs while maintaining variant detection accuracy in genetic studies.

Rare splice and missense variants with evidence of pathogenicity in consanguineous families with autosomal recessive intellectual disability from Pakistan

Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity

The paper identifies nephronectin as a mediator of obesity's effect on COVID-19 severity using proteome-wide Mendelian randomization and validates its expression in lung cells.

Failure to replicate the association of rare loss-of-function variants in type I IFN immunity genes with severe COVID-19

The paper investigates the association of rare loss-of-function variants in type I IFN immunity genes with severe COVID-19 and finds no significant association.

A Neanderthal OAS1 Isoform Protects Against COVID-19 Susceptibility and Severity: Results from Mendelian Randomization and Case-Control Studies

This study identifies OAS1 as a protective factor against COVID-19 severity and susceptibility using Mendelian randomization and case-control analyses.

Genome-wide association study identifies 48 common genetic variants associated with handedness.

This study identifies 48 genetic variants associated with handedness using a large GWAS, highlighting polygenic nature and genetic links to neuropsychiatric traits.