Alban de Kerchove d’Exaerde

Direct and indirect striatal projecting neurons exert strategy-dependent effects on decision-making.

The paper identifies strategy-dependent roles of direct and indirect striatal projecting neurons in decision-making using a mouse gambling task and reinforcement-learning model.

Unexpected contributions of striatal projection neurons coexpressing dopamine D1 and D2 receptors in balancing motor control

The paper identifies D1/D2 coexpressing striatal projection neurons as critical for modulating motor function through interactions with D1- and D2-SPNs.

Nucleus accumbens D1- and D2-expressing neurons control the balance between feeding and activity-mediated energy expenditure

This study investigates the role of NAc D1 and D2 neurons in balancing feeding and exercise-mediated energy expenditure in mice, finding that manipulating these neurons affects energy balance and weight.

Spontaneous activity of striatal projection neurons supports maturation of striatal inputs to substantia nigra dopaminergic neurons

The paper shows that spontaneous activity in striatal projection neurons is essential for the maturation and stabilization of their long-range projections to dopaminergic neurons.

USP7/Maged1-Mediated H2A Monoubiquitination in the Paraventricular Thalamus: An Epigenetic Mechanism Involved in Cocaine Use Disorder

Balance between direct and indirect pathways of the nucleus accumbens controls social behavior in mice

This study investigates the role of D1R- and D2R-SPNs in the nucleus accumbens in modulating social behavior and related neuropsychiatric traits in mice.

Complementary coding of behaviors in striatal pathways supports a dual selection-suppression function

The paper uses calcium imaging and supervised learning to show that direct and indirect striatal pathways encode behaviors through activation and silencing, respectively, supporting a dual selection-suppression function.

Regulation of GluA1 Phosphorylation by D-amphetamine and Methylphenidate in the Cerebellum

This paper shows that d-amphetamine and methylphenidate increase GluA1 phosphorylation at Ser845 in mouse cerebellar Bergmann Glia Cells via norepinephrine signaling.

mTOR-RhoA signalling impairments in direct striatal projection neurons induce altered behaviours and striatal physiology in mice

This study shows that mTOR-RhoA signaling in direct striatal projection neurons affects behavior and striatal physiology in mice, with implications for treating mTOR-related disorders.