Max A. Seibold

Impact of early-life respiratory syncytial virus infection on cell type-specific airway DNA methylation

This study identifies cell type-specific DNA methylation changes in airway epithelial cells linked to early-life RSV infection and their association with subsequent wheezing.

Atopic dermatitis complicated by recurrent eczema herpeticum is characterized by multiple, concurrent epidermal inflammatory endotypes

This study identifies distinct epidermal inflammatory endotypes in atopic dermatitis patients with recurrent eczema herpeticum, showing concurrent type 2 cytokine, interferon, and IL-36γ-driven inflammation and dysregulated epidermal differentiation complex genes.

Type 2 and interferon inflammation strongly regulate SARS-CoV-2 related gene expression in the airway epithelium

The paper identifies eQTLs for ACE2 and TMPRSS2 in children's airway transcriptomes and links their expression to T2 inflammation and interferon responses, influencing SARS-CoV-2 infectivity.

A Genome-wide Association and Admixture Mapping Study of Bronchodilator Drug Response in African Americans with Asthma

This study identifies genetic variants associated with bronchodilator drug response in African Americans with asthma, finding both population-specific and shared genetic factors across African American and Latino populations.

Whole Genome Sequencing of Pharmacogenetic Drug Response in Racially and Ethnically Diverse Children with Asthma

This study identifies pharmacogenetic variants associated with albuterol bronchodilator response in minority children with asthma using whole genome sequencing.

Comprehensive analysis of RNA-sequencing to find the source of 1 trillion reads across diverse adult human tissues

This paper introduces ROP to identify the source of unmapped RNA-Seq reads across diverse tissues, showing it can account for 99.9% of 1 trillion reads and reveals immune and microbial correlations.