Fritjof Helmchen

This study identifies striatum-projecting prefrontal cortex neurons as critical for spatial working memory maintenance in mice.

The paper introduces a database and deep learning tool for spike inference from calcium imaging data, outperforming existing methods with an automated, parameter-free algorithm.

This study uses in vivo calcium imaging to analyze CA3 pyramidal neuron activity in adult mice, showing stable population-level coactivity and state-dependent patterns.

This study uses longitudinal whole-brain imaging to show that anti-Aβ therapies have distinct spatial and temporal efficacies, with polythiophenes showing strong Aβ clearance.

The paper identifies a developmental transition in VIP+ and SST+ interneurons in the mouse barrel cortex around P14, where their responses to multi-whisker stimuli diverge and their thalamic inputs shift.

The paper investigates how sensory input and behavior influence signal routing in the neocortex during short-term memory tasks in mice.

The paper identifies CCK+ S1-CST neurons as a major cortical input to the spinal dorsal horn and characterizes their synaptic connections and molecular diversity.

The paper introduces Opto-E-Dura, a soft, stretchable ECoG array that enables multimodal, multi-scale neuroscience studies through optical and electrical integration.

The paper shows that association cortex in mice undergoes spatiotemporal refinement of activity during whisker-based texture learning, with early suppression followed by task-specific signal flow enhancement.

The paper shows that increasing the excitation-to-inhibition ratio in mouse cortical circuits using chemogenetics reduces long-range connectivity and can be detected via fMRI-based classifiers.

This study investigates how lateral orbitofrontal cortex neurons guide sensory circuits during reversal learning in mice through top-down signals and value prediction error.

The paper introduces vMSOT with AOI987 to quantify Aβ deposition in AD mouse models, revealing strain-specific patterns.

This study shows that motor cortex neuronal populations encode limb movement differently based on environmental context, with M2 influencing this context-dependent encoding.

The paper investigates how locomotion and wall touching modulate neuronal activity in different layers of the mouse barrel cortex, finding distinct patterns in layer 2/3 and layer 5.

This paper introduces high-density multi-fiber photometry arrays for studying brain circuit dynamics in behaving animals, demonstrating simultaneous recordings and optogenetic perturbations across multiple brain regions.

The paper introduces mesoSPIM, an open-source light-sheet microscope initiative for imaging large cleared tissue samples with near-isotropic resolution.

The paper shows that feature binding connectivity in mouse V1 better explains plaid stimulus responses than orientation-tuned connectivity.