Roger L. Clem

Stress History Modulates CRF Neurons to Establish Resilience

The paper identifies a critical stress exposure period that drives neurophysiological changes in CRF neurons, leading to resilience in mice exposed to repeated social defeat stress.

Ventral hippocampal interneurons govern extinction and relapse of contextual associations

The paper shows that ventral hippocampal somatostatin-expressing interneurons are critical for extinguishing contextual associations and preventing relapse of fear or reward responses.

Comparative basolateral amygdala connectomics reveals dissociable single-neuron projection patterns to frontal cortex in macaques and mice

The paper compares single-neuron projection patterns from the basolateral amygdala to the frontal cortex in mice and macaques, finding differences in connectivity organization.

High-throughput sequencing of macaque basolateral amygdala projections reveals dissociable connectional motifs with frontal cortex

The paper uses MAPseq to analyze BLA neuron projections in macaques, finding that many neurons project to multiple brain regions and form structured networks.

The mouse dorsal peduncular cortex encodes fear memory

This study shows that the dorsal peduncular cortex encodes fear memory rather than suppressing it, challenging previous assumptions about its role in fear regulation.

Ensemble-specific deficit in neuronal intrinsic excitability in aged mice

The paper investigates age-related changes in neuronal excitability in the hippocampus of mice, finding that aged mice show a deficit in ensemble-specific excitability after learning, linked to memory impairment.

Ensemble encoding of conditioned fear by prefrontal somatostatin interneurons

This study identifies a heterogeneous neural ensemble in the medial prefrontal cortex involved in fear conditioning, highlighting the role of somatostatin interneurons in memory encoding and behavior.

Adolescent frontal top-down neurons receive heightened local drive to establish adult attentional behavior in mice

This study identifies an adolescent-sensitive period for top-down neurons in mice, where heightened local drive during adolescence leads to long-term attentional behavior changes.

Prefrontal somatostatin interneurons encode fear memory

This study shows that fear memory encoding involves activation of prefrontal somatostatin interneurons, challenging the view that they only modulate network activity.

Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior

This study shows orexin signaling in GABAergic lateral habenula neurons promotes aggression and conditioned place preference, suggesting a potential therapeutic target for reducing aggressive behaviors.