Atsushi Fujimoto

Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks

This study shows that deep brain stimulation remodels white matter and alters brain-wide functional connectivity in macaques, contributing to its therapeutic effects.

Pharmacological modulation of dopamine D1 and D2 receptors reveals distinct neural networks related to probabilistic learning in non-human primates.

This study examines the effects of D1 and D2 receptor antagonists on probabilistic learning and brain connectivity in macaques, revealing distinct neural networks associated with learning and motivation.

Ventrolateral prefrontal cortex in macaques guides decisions in different learning contexts

This study investigates how vlPFC activity and connectivity guide decision-making in different learning contexts using rhesus macaques.

Distinct roles of monkey OFC-subcortical pathways in adaptive behavior

This study identifies distinct OFC-subcortical pathways in macaques that support experience-based and inference-based value updating during adaptive decision-making.

The neural basis of resting-state fMRI functional connectivity in fronto-limbic circuits revealed by chemogenetic manipulation

This study uses chemogenetic manipulation in macaques to show that activating inhibitory DREADDs in the amygdala increases resting-state fMRI functional connectivity between the amygdala and ventrolateral prefrontal cortex.

High-throughput sequencing of macaque basolateral amygdala projections reveals dissociable connectional motifs with frontal cortex

The paper uses MAPseq to analyze BLA neuron projections in macaques, finding that many neurons project to multiple brain regions and form structured networks.

Resting-state fMRI-based screening of deschloroclozapine in rhesus macaques predicts dosage-dependent behavioral effects

This study uses resting-state fMRI to screen deschloroclozapine in rhesus macaques, showing dosage-dependent changes in brain connectivity and behavioral effects.

Interaction between decision-making and interoceptive representations of bodily arousal in frontal cortex

The paper investigates how bodily arousal affects decision-making in macaques by analyzing neural activity in the orbitofrontal cortex and dorsal anterior cingulate cortex, showing changes in HR encoding after amygdala lesions.

Single caudate neurons encode temporally discounted value for formulating motivation for action

The paper shows that neurons in the primate caudate head encode temporally discounted value for delayed rewards, essential for motivation.

Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys

This paper introduces deschloroclozapine (DCZ), a potent and selective DREADD agonist that rapidly modulates neuronal activity and behavior in mice and monkeys.

Signaling incentive and drive in the primate ventral pallidum for motivational control of goal-directed action

This study investigates how the ventral pallidum and rostromedial caudate encode reward size and satiation level in macaques performing a lever-release task, showing VP has stronger coding and more severe inactivation effects on goal-directed behavior.