Santhi Gorantla

HIV Infection in Humanized Microglial Mice Disrupts Feeding Behavior and Circadian Rhythms with Cortical Neuroinflammation

This study shows HIV infection in humanized mice causes feeding behavior changes, circadian rhythm disruption, and cortical inflammation, using a new model to study HAND.

Accelerated amyloid neurodegeneration in HIV-1-infected APP-KI Alzheimer's disease mice

This study shows that HIV-1 infection accelerates amyloid pathology and neurodegeneration in a novel AD mouse model with human microglia-like cells.

Impaired extinction of cocaine seeking in HIV-infected mice is accompanied by peripheral and central immune dysregulation

This study shows HIV-infected mice show impaired extinction of cocaine-seeking behavior and associated immune dysregulation in both peripheral and central systems.

Alzheimer's disease brain-derived tau-containing extracellular vesicles: Pathobiology and GABAergic neuronal transmission

This study investigates how Alzheimer's disease-derived extracellular vesicles propagate tau pathology and affect GABAergic neuronal transmission.

Systemic HIV-1 Infection Produces a Unique Glial Footprint in Humanized Mouse Brains

This paper creates a humanized mouse model to study HIV-1's effects on glial cells, finding human-specific transcriptional changes in antiviral responses and myelination.