Ilona C Grunwald Kadow

Deep Representation Learning on Whole-Brain Population Dynamics Uncovers Geometrically Separable Neural Codes

The paper develops a deep-learning framework to learn interpretable representations of whole-brain neural dynamics in Drosophila without neuronal identification, revealing factorized organization along metabolic state, sensory modality, and stimulus valence axes.

Reduced dopaminergic reinforcement, not learning capacity, limits operant learning in aging Drosophila

This study shows that aging in Drosophila impairs dopaminergic reinforcement rather than learning capacity, with specific subtype vulnerabilities in dopaminergic neurons.

A Bidirectional Brain-Fat Body Axis for Pathogen Avoidance

The paper identifies a bidirectional communication pathway between the fat body and the nervous system that drives pathogen avoidance behavior in response to immune receptor signaling.

Avoidance engages dopaminergic punishment in Drosophila

The paper shows that inducing backward movement in Drosophila engages dopaminergic punishment and supports aversive memories, explaining the avoidance paradox.

The Innexin 7 gap junction protein contributes to synchronized activity in the Drosophila antennal lobe and regulates olfactory function

This study shows that Inx7 gap junctions synchronize antennal lobe projection neurons and are essential for olfactory function in Drosophila.

Adenosine signaling in glia modulates metabolic state-dependent behavior in Drosophila

This study shows that adenosine signaling in specific glia subtypes modulates metabolic state-dependent behavior in Drosophila by altering intracellular calcium levels.

The Preoptic Area and Dorsal Habenula Jointly Support Homeostatic Navigation in Larval Zebrafish

This study identifies a neural network connecting the preoptic area and habenula in larval zebrafish that supports thermoregulation through movement and spatial navigation.

Optimized design and in vivo application of optogenetically functionalized Drosophila dopamine receptors

This paper optimizes optogenetically functionalized GPCRs to achieve specific in vivo neuromodulatory signaling in Drosophila, showing rescue of endogenous receptor function.

Combined patterns of activity of major neuronal classes underpin a global change in brain state during spontaneous and forced walk in Drosophila

The paper examines brain activity during walking in Drosophila, finding global but heterogeneous patterns of neuronal activity associated with both spontaneous and forced walking.

A dopamine-gated learning circuit underpins reproductive state-dependent odor preference in Drosophila females

The paper identifies a dopamine-gated learning circuit in Drosophila females that links mating experiences to long-lasting changes in odor preference behavior.

Valence and state-dependent population coding in dopaminergic neurons in the fly mushroom body

The paper investigates how dopaminergic neurons in the fly mushroom body encode sensory valence and behavioral state through population activity.

A neural circuit arbitrates between perseverance and withdrawal in hungry Drosophila

The paper shows that hungry Drosophila use a neural circuit involving dopamine and octopamine to balance perseverance and withdrawal during food seeking.