Tristan R. McKay

PDLIM5 Modulates YAP1 Localisation and Fibrogenic Gene Expression in Hepatic Stellate Cells

This study shows that PDLIM5 regulates YAP1 localization and fibrogenic gene expression in hepatic stellate cells through mechanical cues.

Dysregulated Wnt and NFAT signaling in a Parkinson's disease LRRK2 G2019S knock-in model

This study investigates the impact of LRRK2 G2019S mutation on Wnt and NFAT signaling in Parkinson's disease models, finding significant dysregulation in specific brain regions.

Mitochondrial collapse links PFKFB3-promoted glycolysis with CLN7/MFSD8 neuronal ceroid lipofuscinosis pathogenesis

This study identifies a metabolic shift driven by PFKFB3 in CLN7 disease, showing that targeting glycolysis can alleviate disease hallmarks in a mouse model and patient-derived cells.

Generation of light-producing somatic-transgenic mice using adeno-associated virus vectors

The paper develops a method using adeno-associated virus vectors to generate somatic-transgenic mice for non-invasive monitoring of signaling pathways in disease models.