Iwo Kuciński

Deploying cross-species bone marrow niches to elucidate human hematopoietic stem cell regulation in vivo

This study uses a cross-species bone marrow niche model to show that plasticity in the murine niche supports human HSC engraftment, highlighting its role in stem cell function.

Selection of pre-leukemic hematopoietic stem cells driven by distinct extracellular matrix molecules

The paper characterizes Tet2-mutant HSCs using multi-omic data and identifies ECM molecules as regulators of self-renewal in pre-leukemic HSCs.

Distinct molecular profile of the chick Organizer as a stem zone during axial elongation

The paper identifies four genes upregulated in the chick Organizer stem zone during axial elongation, defining its molecular identity.

Intrinsic and extrinsic regulation of human fetal bone marrow haematopoiesis and perturbations in Down syndrome

This study uses single-cell RNA-sequencing to analyze fetal bone marrow development and identifies disruptions in hematopoiesis in Down syndrome.

Ribosome protein mutant cells rely on the GR64 cluster of gustatory receptors for survival and proteostasis in Drosophila

The paper shows that Rp/+ cells in Drosophila rely on Gr64 gustatory receptors for survival and proteostasis by maintaining autophagy and proteasome function.

Neuromesodermal progenitors separate the axial stem zones while producing few single- and dual-fated descendants

The paper shows that multipotent progenitors separate specialized stem zones in chick embryos through extrinsic morphogenetic cues rather than intrinsic fate determination.