Ewa K. Paluch

This paper introduces Intrinsic3D, a 3D SMLM method that enables rapid, whole-cell protein mapping with nanometre resolution, demonstrating its application in studying cell adhesion structures.

The paper compares cellular behaviours during insect gastrulation, finding divergent mechanisms between Drosophila and Tribolium, with nuclear crowding influencing internalisation modes.

This study shows basement membrane mechanics regulate the spatial response to BMP4 in hPSCs and mouse embryos, disrupting gastrulation patterning when mechanics are altered.

This study shows that increased cell shape noise during EMT accelerates shape transitions by facilitating movement between shape attractors.

This study uses cryo-ET to reveal the nanoscale 3D organization of cortical actin in cellular blebs, showing short and straight actin filaments and structural parameters.

The paper identifies dynamic cell surface fluctuations as a key factor in early embryonic lineage sorting, showing that increased surface fluctuations in primitive endoderm precursors drive their segregation from epiblast precursors.

The paper develops a single-cell morphometrics pipeline to study notochord development in amphioxus, revealing ancestral principles of morphogenesis and growth regulation.

The paper shows that tissue mechanics influence mitotic nuclear migration in Drosophila wing disc epithelia, with Rho kinase and Diaphanous playing key roles in nuclear positioning under varying cell density.