Anne Brelot

Characterizing particle dynamics in live imaging through stochastic physical models and machine learning

This paper develops a machine learning method to classify subdiffusive particle dynamics in live imaging, showing it can distinguish different motion behaviors and reveal how receptor dynamics relate to HIV-1 activity.

Bridging the resolution gap in cryo-CLEM by introducing cryo-SXT: cryo-CLXEM

This paper introduces cryo-SXT as an intermediate technique to bridge the resolution gap in cryo-CLEM by providing 3D cellular context to cryo-ET datasets.

SARS-CoV-2 entry and fusion are independent of ACE2 localization to lipid rafts

This study shows that SARS-CoV-2 entry and fusion depend on cholesterol but not on ACE2 localization to lipid rafts.

Intranasal delivery of a broadly neutralizing single domain antibody targeting ACE2 protects against SARS-CoV-2 infection

This paper develops a single domain antibody targeting ACE2 that protects against SARS-CoV-2 infection in mice when delivered intranasally.

Differential screening identifies molecules specifically inhibiting CCR5 transport to the cell surface and HIV infection

The paper identifies molecules that inhibit CCR5 transport to the cell surface and HIV infection by targeting palmitoylation.