Howard A. Stone

An implantable sensor network for large-scale cellular force mapping in living embryos

The paper introduces FORCENET, an implantable sensor network that maps intercellular forces in living embryos, revealing coordinated mechanical patterns regulated by developmental signaling.

Emergence of large-scale polar microtubule swarms for dense molecular transport

This study demonstrates the formation of large-scale polar microtubule swarms that enable dense molecular transport through motor-driven activity and filament regeneration.

Capillary bundling of microtubules by condensates

This study demonstrates that microtubule bundling can occur through condensate-mediated capillary forces, independent of bulk protein concentration.

Electric charge controls plasmodesma conductivity

The paper shows that anionic fluorescent dyes up to 1 kDa pass through plasmodesmata while smaller cationic ones do not, suggesting plasmodesmal pores may have positive charges.

Suspension physics govern the multiscale dynamics of blood flow in sickle cell disease

This study uses a microfluidic platform to link red blood cell properties to whole-blood rheology in sickle cell disease, revealing how stiff cell proportions and spatial organization drive pathological flow resistance.

Room-Temperature Aerosol Dehydration of Green Fluorescent Protein

This study uses Green Fluorescent Protein to optimize a room-temperature aerosol dehydration process, achieving over 96% fluorescence recovery in dry powders.

Boundary-Sensing Mechanism in Branched Microtubule Networks

This paper demonstrates a boundary-sensing mechanism in branched microtubule networks using a nanotechnology platform, showing how length-dependent branching and dynamic instability enable tunable network formation in confined spaces.

A handheld microfluidic manifold for massively multiplexed nucleic acid detection

This paper introduces a portable microfluidic device for highly multiplexed nucleic acid detection, demonstrating its integration with CRISPR-based technology for rapid pathogen and variant detection.

Sperm hyperactivation drives a circling-and-wandering migration strategy

The paper studies sperm hyperactivation in different fluid environments, identifying three migration strategies and showing how circling-and-wandering balances exploration and exploitation for effective migration.

Spatial gene drives and pushed genetic waves

The paper models how gene drives spread spatially and identifies conditions for controlled release and containment.