Author

Diane C. Shakes

William & MaryORCID 0000-0002-9677-5577Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:C. elegans· 4 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

André Pires‐daSilvaiD· 2 shared James Matthew RagleiD· 2 shared Jordan D. WardiD· 2 shared Kayleigh N. MorrisoniD· 2 shared Abigail L. AitaiD· 1 shared Amber R. KrauchunasiD· 1 shared An A. VoiD· 1 shared Andreas RechtsteineriD· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersDevelopmental Biology

André Pires‐daSilvaORCID

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6 papers

Recent·Most cited

The X chromosome is a potential polarising signal for asymmetric cell divisions in meiotic cells of a nematode

Talal Al‐Yazeedi, Emily L Xu, Jasmin Kaur, Diane C. Shakes, André Pires‐daSilva

The paper identifies the X chromosome as a polarising signal for asymmetric cell division in nematode meiotic cells, where it directs the segregation of essential sperm components.

Genetics · Oct 18, 2022Peer-reviewedDevelopmental Biology

NHR-23 and SPE-44 regulate distinct sets of genes during C. elegans spermatogenesis

James Matthew Ragle, Kayleigh N. Morrison, An A. Vo, Zoe E. Johnson, Javier Hernandez Lopez, Andreas Rechtsteiner, Diane C. Shakes, Jordan D. Ward

The paper identifies distinct gene regulation by NHR-23 and SPE-44 during C. elegans spermatogenesis and shows their combined depletion affects additional genes.

G3 Genes Genomes Genetics · Sep 22, 2022Peer-reviewedGenetics

SPE-51, a sperm secreted protein with an Immunoglobulin-like domain, is required for sperm-egg fusion in C. elegans

Xue Mei, Marina K. Druzhinina, Sunny Dharia, Amber R. Krauchunas, Julie Zhouli Ni, Gunasekaran Singaravelu, Sam Guoping Gu, Diane C. Shakes, Barth D. Grant, Andrew W. Singson

The paper identifies SPE-51, a secreted protein in C. elegans, essential for sperm-egg fusion, and shows it localizes to the sperm surface.

bioRxiv · Jul 7, 2021 · PreprintDevelopmental Biology

The intrinsically disordered protein SPE-18 promotes localized assembly of the major sperm protein in C. elegans spermatocytes

Kari L. Price, Marc Presler, Christopher M. Uyehara, Diane C. Shakes

This study identifies SPE-18 as an intrinsically disordered protein essential for localized MSP assembly in C. elegans spermatocytes, revealing a novel strategy for cytoskeletal element sequestration.

Development · Feb 8, 2021Peer-reviewedDevelopmental Biology

The conserved molting/circadian rhythm regulator NHR-23/NR1F1 serves as an essential co-regulator of C. elegans spermatogenesis

James Matthew Ragle, Abigail L. Aita, Kayleigh N. Morrison, Raquel Martínez-Méndez, Hannah N. Saeger, Guinevere E. Ashley, Londen C. Johnson, Katherine Schubert, Diane C. Shakes, Jordan D. Ward

This study identifies NHR-23/NR1F1 as a critical regulator of spermatogenesis in C. elegans, functioning downstream of the sex determination pathway and independent of the SPE-44 network.

Development · Jan 1, 2020Peer-reviewedDevelopmental Biology

Gender- and gamete-specific patterns of X chromosome segregation in a three-gendered nematode

Sophie Tandonnet, Maureen Farrell, Georgios Koutsovoulos, Mark Blaxter, Manish Parihar, Penny L. Sadler, Diane C. Shakes, André Pires‐daSilva

The paper studies X chromosome segregation patterns in a three-gendered nematode, revealing gender- and gamete-specific meiotic variations.

Current Biology · Dec 21, 2017Peer-reviewedGenetics