Internalized Components of Membrane Attack Complexes Disrupt Proteostasis and Acquire Alarmin-Like Properties
宋贵玉, Zihan Ma, Matthew Fan, Liying He, Yulong Lan, Weihao Li, Zhengtao Jiang, Quan Jiang, Dylan P. Noone, Andrea Nans, Kamal L. Nahas, Mahsa Nouri Barkestani, Shaoxun Wang, Qianxun Wang, Pengwei Ren, , Dan Jane‐wit
This study shows that C9, a component of membrane attack complexes, forms non-cytolytic intracellular aggregates that promote inflammation and EC activation through aggrephagy and NF-κB activation.
Nature Communications · Jul 17, 2026Peer-reviewedBiochemistry