Isabel Zhang

The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube

This study identifies a global temporal chromatin programme in vertebrate neural progenitors that integrates with spatial patterning to regulate cell fate and identity.

Developmental cell fate choice employs two distinct cis regulatory strategies

The paper identifies two distinct cis regulatory strategies used by CREs to translate graded Shh signaling into differential gene expression in neural progenitors.

Temporal patterning of the central nervous system by a shared transcription factor code

The paper identifies a temporal patterning program in vertebrate neurons controlled by transcription factors and the TGFβ pathway, showing its role in generating neuronal diversity.