Ming‐Sound Tsao

Tumor Microenvironment Modulates Lineage Plasticity in Lung Squamous Cell Carcinoma

This study shows that the tumor microenvironment influences lineage plasticity in lung squamous cell carcinoma by modulating HIF1 and SOX2 pathways and ECM remodeling.

mSWI/SNF complex inhibition sensitizes KRAS-mutant lung cancers to targeted therapies via epithelial-mesenchymal subversion

This study shows that inhibiting mSWI/SNF complexes enhances the effectiveness of KRAS inhibitors in lung cancers by reversing epithelial-mesenchymal transition resistance.

Pan-cancer N-glycoproteomic atlas of patient derived xenografts uncovers FAT2 as a therapeutic target for head and neck cancers

This paper uses N-glycoproteomics to analyze patient-derived xenografts, identifies FAT2 as a therapeutic target for head and neck cancers, and validates its role in tumor growth and CAR T cell activity.

Bona fide cytotoxic iNKT cells with superior antitumour responses identified in mice and humans

This study identifies specific iNKT cell subsets in mice and humans with enhanced antitumor activity, suggesting potential improvements for adoptive cell therapies.

Detection of circular RNAs and their potential as biomarkers predictive of drug response

The paper assesses the inter-lab consistency of circular RNA expression in cancer cell lines and identifies factors affecting reproducibility.

KuLGaP: A Selective Measure for Assessing Therapy Response in Patient-Derived Xenografts

The paper introduces KuLGaP, a selective measure to assess therapy response in patient-derived xenografts by comparing treatment and control arms, improving accuracy over existing methods.

Integrative Pharmacogenomics Analysis of Patient Derived Xenografts

The paper develops Xeva, an open-source tool for analyzing PDX pharmacogenomic data, finding that few genes and pathways show passage-specific changes.

Evosep One Enables Robust Quantitative Deep Proteome Coverage using Tandem Mass Tags while Significantly Reducing Instrument Time

The paper demonstrates that Evosep One technology enables faster quantitative proteome analysis with comparable coverage to conventional methods.

Whole Genomes Define Concordance of Matched Primary, Xenograft, and Organoid Models of Pancreas Cancer

The paper compares whole-genome data from primary pancreatic cancer, xenografts, and organoids to assess genetic concordance across different models.