Author

Ofer Reizes

Cleveland ClinicORCID 0000-0003-0075-6871Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Akeem SantosiD· 1 shared Annette BellariD· 1 shared Anthony J. HorakiD· 1 shared Austin M Williams· 1 shared Daniela S. AllendeiD· 1 shared David W. StreemiD· 1 shared Emily HuangiD· 1 shared Isabella JamesiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

Akeem SantosORCID

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2 papers

Recent·Most cited

Metabolic engineering of Salmonella enterica for coupled kynurenine sensing and depletion enhances antitumor efficacy

Kontham Kulangara Varsha, Akeem Santos, Tingting Xiao, Zeneng Wang, Rashmi Bharti, Mahima Arora, Austin M Williams, John Peterson, Justin D. Lathia, Stanley L. Hazen, Nan Zhang, Philip P. Ahern, Ofer Reizes, Mohammed Dwidar

This paper engineers Salmonella enterica to sense and deplete kynurenine in tumors, enhancing antitumor immune responses and efficacy in mouse models.

bioRxiv · Sep 24, 2026 · PreprintCancer Biology

Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury

Venkateshwari Varadharajan, Iyappan Ramachandiran, William J. Massey, Raghav Jain, Rakhee Banerjee, Anthony J. Horak, Megan R. McMullen, Emily Huang, Annette Bellar, Shuhui Wang Lorkowski, Kailash Gulshan, Robert Nathaniel Helsley, Isabella James, Vai Pathak, Jaividhya Dasarathy, , Jonathan Mark Brown

This study shows that MBOAT7 loss of function in hepatocytes causes ethanol-induced liver injury by disrupting lysosomal biogenesis and autophagic flux.

eLife · Dec 27, 2023Peer-reviewedMolecular Biology