Author

Yungui Zhou

Gladstone Institutes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 5

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:mouse· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

Li GaniD· 5 shared Lay KodamaiD· 4 shared Yaqiao LiiD· 4 shared David LeiD· 3 shared Li FaniD· 3 shared Lihong ZhaniD· 3 shared Man Ying WongiD· 3 shared Maria A. TelpoukhovskaiaiD· 3 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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5 shared papersNeuroscience

Li GanORCID

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5 papers

Recent·Most cited

Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

Chao Wang, Li Fan, Rabia R. Khawaja, Bangyan Liu, Lihong Zhan, Lay Kodama, Marcus Y. Chin, Yaqiao Li, David Le, Yungui Zhou, Carlo Condello, Lea T. Grinberg, William W. Seeley, Bruce L. Miller, Sue‐Ann Mok, , Li Gan

This study shows that microglial NF-κB signaling drives tau spreading and toxicity in a mouse model of tauopathy, with inhibition reducing tau pathology and cognitive deficits.

Nature Communications · Apr 12, 2022Peer-reviewedNeuroscience

Tau interactome mapping reveals dynamic processes in synapses and mitochondria associated with neurodegenerative disease

Tara E. Tracy, Jesús Madero‐Pérez, Danielle L. Swaney, Timothy S. Chang, Michelle Moritz, Csaba Konràd, Michael Emmerson Ward, Erica J. Stevenson, Ruth Hüttenhain, Grant Kauwe, María del Pilar Hernández Mercedes, Lauren Sweetland-Martin, Xu Chen, Sue‐Ann Mok, Man Ying Wong, , Li Gan

The paper maps Tau interactomes in neurons using APEX and AP-MS to reveal activity-dependent interactions and FTD mutation effects on mitochondrial associations in neurodegenerative diseases.

Cell · Jan 20, 2022Peer-reviewedNeuroscience

A Mac2-positive progenitor-like microglial population survives independent of CSF1R signaling in adult mouse brain

Lihong Zhan, Li Fan, Lay Kodama, Peter Sohn, Man Ying Wong, Gergey Alzaem Mousa, Yungui Zhou, Yaqiao Li, Li Gan

The paper identifies a Csf1r-independent microglial subset in adult mice that exhibits progenitor-like features and is distinct from homeostatic microglia.

eLife · Oct 15, 2020Peer-reviewedNeuroscience

AD-linked R47H-TREM2 mutation induces disease-enhancing proinflammatory microglial states in mice and humans

Faten A. Sayed, Lay Kodama, Joe C. Udeochu, Li Fan, Gillian Carling, David Le, Qingyun Li, Lu Zhou, Hansruedi Mathys, Minghui Wang, Xiang Niu, Linas Mažutis, Xueqiao Jiang, Xueting Wang, Man Ying Wong, , Li Gan

This study identifies R47H-TREM2 mutation-induced proinflammatory microglial states in human AD and tauopathy mice, showing Akt pathway involvement and potential therapeutic targets.

bioRxiv · Jul 24, 2020 · PreprintNeuroscience

Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain

Lihong Zhan, Grietje Krabbe, Fei Du, Ian Richard Jones, Meredith C. Reichert, Maria A. Telpoukhovskaia, Lay Kodama, Chao Wang, Seo-Hyun Cho, Faten A. Sayed, Yaqiao Li, David Le, Yungui Zhou, Yin Shen, Brian L. West, Li Gan

This study shows that adult microglia self-renew to restore homeostasis after ablation, with specific maturation programs and spatial organization.

PLoS Biology · Feb 8, 2019Peer-reviewedNeuroscience