Walter Birchmeier

This study uses spatial transcriptomics to analyze tumor microenvironment remodeling dynamics in triple-negative breast cancer, identifying early stromal programs as potential therapeutic targets.

This study shows that MLL1 is essential for intestinal stem cell maintenance and regulates the expression of JAML, a cell adhesion molecule critical for stem cell niche interactions.

The paper shows that reduced Wnt/β-catenin signaling in microglia of the developing brain causes pro-inflammatory activation and white matter injury, and that restoring this pathway can prevent these effects.