Sriram Balusu

This study shows microglia initially seed amyloid plaques in Alzheimer's disease but later help compact them, with genetic and pharmacological manipulation affecting plaque formation.

This study identifies distinct microglial responses to amyloid-beta in AD using single-cell data, highlighting HLA-related and cytokine responses and their genetic modulation.

The paper shows that MEG3, a long noncoding RNA, induces necroptosis in human neurons exposed to amyloid pathology, mimicking AD features in a xenograft model.

The paper uses spatial transcriptomics and in situ sequencing to study gene networks in the amyloid-β plaque niche of AD, revealing microglia-astroglia interactions and myelination abnormalities.

This study identifies miR-132 deficiency as a cause of impaired adult hippocampal neurogenesis in Alzheimer's disease and shows that restoring miR-132 levels can reverse these deficits and memory issues.

The paper demonstrates that human microglia derived from embryonic stem cells can engraft mouse brains and express Alzheimer's risk genes when exposed to Aβ, offering a new model to study genetic risk in AD.