Rainer Kurre

VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair

This study identifies VPS13C/PARK23 as a key protein involved in lysosomal repair by facilitating lipid transfer and membrane remodeling in response to damage.

Human-restricted Salmonella exploit preassembled flagella for intracellular motility and vacuolar escape

This study shows human-restricted Salmonella retain preassembled flagella during host cell invasion, using them for intracellular motility and vacuolar escape, while non-typhoidal Salmonella do not.

Metal-induced energy transfer uncovers activation-induced axial reorganization of signaling complexes inside cells

This study uses metal-induced energy transfer to reveal that cytokine receptor intracellular domains compact upon activation.

A Versatile Toolbox for Nanoscale Interrogation of Multiprotein Assemblies inside Living Cells

This paper introduces a nanopatterning toolbox to study multiprotein assemblies in live cells, demonstrating its application to the myddosome complex and revealing nanoscale organization.

Long-term single molecule localization microscopy uncovers dynamic co-assembly of Lrp6 and Ror2 into Wnt-signalosomes

This study uses single-molecule tracking to show that Lrp6 and Ror2 co-assemble into hybrid Wnt signalosomes dynamically.

Tagging of Exo70 at the N-terminus compromises its assembly with the exocyst complex and changes its spatiotemporal behavior at the plasma membrane

This paper shows that N-terminal tagging of Exo70 disrupts its assembly with the exocyst complex and alters its spatiotemporal behavior at the plasma membrane.

Rapid in-EPON CLEM for everyone: Combining fast and efficient labeling of self-labeling enzyme tags with EM resistant Janelia Fluor dyes

The paper compares Janelia Fluor dyes and TMR for fluorescence preservation in EM-compatible in-resin CLEM, identifying JFX549 and JFX554 as optimal for signal intensity and background ratio.

Tau and α-synuclein shape microtubule organization and microtubule-dependent transport in neuronal dendrites

This study shows that tau and α-synuclein regulate microtubule organization and transport in neuronal dendrites, with tau deficiency increasing dendritic complexity and transport efficiency.