George McDonald Church

The paper quantifies error correction in gene synthesis using next-generation sequencing, finding ErrASE and T7 Endonuclease I most effective at reducing error rates.

The paper critiques the experimental design and data interpretation in a previous study claiming CRISPR-Cas9 causes unexpected mutations, arguing the conclusions are not supported by the evidence.

The paper presents a method combining multiplex genome engineering and predictive modeling to identify minimal genomic modifications that optimize a complex phenotype in E. coli.

Millstone is a web-based platform for microbial genome analysis and engineering that automates genotype comparison and visualization for projects with up to hundreds of genomic samples.

This study demonstrates that {lambda}-Red homologs from the SXT mobile element in Vibrio natriegens enable highly efficient recombineering, enabling genomic modifications and advancing genetic engineering capabilities.

This paper introduces a homing CRISPR system that generates evolving DNA barcodes in living cells, enabling lineage tracking and molecular recording.