Author

Ismar Klebic

University of Bern

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Ewa GogolaiD· 2 shared Jos JonkersiD· 2 shared Merve MutluiD· 2 shared Paola FrancicaiD· 2 shared Sven RottenbergiD· 2 shared Alexandra A. Duarte· 1 shared Arnab Ray ChaudhuriiD· 1 shared Arunasalam NaguleswaraniD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Ewa GogolaORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

TAOK1 regulates chemo- and radiosensitivity in BRCA1/2-deficient tumors

Lea Lingg, Merve Mutlu, Arunasalam Naguleswaran, Ismar Klebic, Ewa Gogola, Dilara Akhoundova, Pascale Martine Schürch, Raviprasad Kuthethur, Carmen Fonseca, Simone de Brot, Marieke Everts, Martín González Fernández, Saskia Hussung, Erik Vassella, Marcel A.T.M. van Vugt, , Paola Francica

This study identifies TAOK1 as a regulator of replication fork stability in BRCA1/2-deficient tumors, showing it enhances sensitivity to PARPi and IR through PCNA and ISG15 interactions.

bioRxiv · Oct 14, 2025 · PreprintCancer Biology

MDC1 counteracts restrained replication fork restart and its loss causes chemoresistance in BRCA1/2-deficient mammary tumors

Martin Liptay, Joana S. Barbosa, Ewa Gogola, Alexandra A. Duarte, Diego Dibitetto, Jonas Andreas Schmid, Ismar Klebic, Merve Mutlu, Myriam Siffert, Paola Francica, Israel Salguero, Marieke van de Ven, Renske de Korte‐Grimmerink, Stephen P. Jackson, Jos Jonkers, , Sven Rottenberg

This study identifies MDC1's role in replication fork restart and shows its loss leads to chemoresistance in BRCA1/2-deficient mammary tumors.

bioRxiv · Aug 18, 2022 · PreprintMolecular Biology