Michael J. Taormina

3D-MAESTRO automates processing of large-scale volumetric brain microscopy data, enabling scalable and reproducible analysis of mouse brain structures.

The paper develops a cross-species enhancer-AAV toolkit for targeting specific cell types in the basal ganglia across species, validated in mouse and macaque.

The paper develops a toolkit of transgenic mouse lines and enhancer AAVs for selective targeting of cortical cell populations using transcriptomic and epigenomic data.

The paper creates high-resolution 3D atlases of postnatal mouse brains and maps changes in GABAergic cells and microglia across development.

The paper visualizes dense distributions of immunolabeled proteins in adult macaque visual cortex using expansion microscopy and light sheet imaging, enabling multimodal atlas creation.

The paper develops AAV-based genetic tools to specifically target astrocytes and oligodendrocytes across species, revealing functional roles in reward-dependent acetylcholine responses.

The paper investigates target cell-specific synaptic dynamics between excitatory and inhibitory neurons in human neocortex, finding similarities to rodent studies.

The paper maps brain-wide monosynaptic inputs to specific neuron classes in mouse visual cortex using an improved rabies virus tracing strategy and identifies connectivity patterns within and between visual areas.

The paper characterizes fiber-coupled illumination systems for fluorescence microscopy, comparing speckle reduction schemes and introducing a new design called the EvenField Illuminator.

The paper presents a method combining spatial transcriptomics with optogenetic mapping to resolve cell type characteristics in mouse cortex.