Guanbo Wang

Structural streamlining of axonemal doublet microtubules in Plasmodium male gametes

The paper examines the structural and molecular architecture of axonemes in Plasmodium male gametes, revealing unique remodeling and assembly mechanisms during rapid gametogenesis.

High-plex spatial RNA imaging in one round with conventional microscopes using color-intensity barcodes

This paper introduces PRISM, a method for high-plex spatial RNA imaging using color intensity barcodes, validated across multiple tissues and showing the role of CAFs in tumor microenvironments.

HLA-DQ2/8 genotype is associated with strain-level gut microbiome divergence and lower serum pantothenate in healthy adults

Deepening imaging-based spatial proteomics at high spatial resolution through controlled tissue resizing and in-situ bottom-up mass spectrometry

The paper introduces IMPACT, a method to enhance spatial proteomics resolution and sensitivity through tissue compression and optimized digestion, demonstrating improved protein detection and anatomical resolution.

Rapid and Signal Crowdedness-Robust In-Situ Sequencing through Hybrid Block Coding

The paper introduces SPRINTseq, a spatial transcriptomics method that enables fast, sensitive, and high-resolution data acquisition, revealing cellular and subcellular molecular architecture in Alzheimer's disease.

Proteomic analysis of human milk reveals nutritional and immune benefits in the colostrum from mothers with COVID-19

This study uses proteomic analysis to show that colostrum from mothers with COVID-19 has increased immune-related proteins and glycosylation, suggesting potential protective benefits against SARS-CoV-2.

RNA Sequencing by Direct Tagmentation of RNA/DNA Hybrids

This paper introduces SHERRY, a new RNA-seq method that avoids second strand synthesis by using Tn5 transposase to directly fragment and prime RNA/DNA hybrids, improving reproducibility and GC uniformity.