Nicholas Garaffo

This study identifies FBXO42's role in regulating PPP4C and p53 signaling, showing its importance in cancer cell survival through genetic and proteomic analyses.

The paper shows that p53 protein abundance in TP53 mutant cancers can be exploited to selectively kill these cells using proximity-inducing small molecules.

The paper identifies BCL2 proteins as co-receptors for CUL5WSB2 to target BIM for degradation, revealing a novel mechanism in apoptosis regulation with therapeutic implications for neuroblastomas and cancers.