Nikhil Nageshwar Inturi

This study identifies E-selectin as a key driver of IL-1B-dependent neuroinflammation in vincristine-induced neuropathy and suggests targeting E-selectin as a therapeutic strategy.

This study shows that translational control in spinal cord neurons, particularly in inhibitory and PV+ interneurons, significantly influences gene expression and pain hypersensitivity during the chronic phase of neuropathic pain.

The paper identifies OSMR and SST as molecular markers for human dermal sleeping nociceptors, providing new therapeutic targets for neuropathic pain.

The paper investigates neurodegeneration in dorsal root ganglia across diabetes and diabetic painful neuropathy stages, identifying early molecular changes and highlighting the need for early intervention.

This study shows that 4E-BP2 controls specific mRNA translation in GABAergic interneurons, which is necessary for long-term memory formation.

This paper constructs a human dorsal root ganglion reference atlas, identifying 22 neuronal subtypes and 10 non-neuronal cell types, and reveals functional differences between human and mouse DRG neurons.

The paper maps molecular features of human spinal cord dorsal and ventral horns, identifying neuronal types and sex-specific glial differences using single-nucleus sequencing and spatial transcriptomics.

This study identifies transcriptomic signatures in GBS patients that reveal leukocyte interactions with peripheral nerves and pain pathways, suggesting therapeutic targets for neuropathic pain.

This study uses bulk and spatial RNA sequencing to analyze human peripheral nerves in diabetic patients, revealing pathway differences, immune cell shifts, and mRNA localization changes linked to diabetic peripheral neuropathy.

This paper uses spatial transcriptomics to analyze human sympathetic chain ganglia in diabetes, identifying neuronal and non-neuronal changes linked to autonomic dysfunction.

The paper shows OSM-OSMR signaling via MAPKs drives transcriptomic changes in human DRG linked to neuropathic pain.

The paper characterizes human C2 dorsal root ganglion (DRG) using single-nucleus and spatial transcriptomics, identifying gene expression patterns linked to chronic neck pain.

The paper examines sex differences in the epigenomic landscape of human dorsal root ganglia, identifying sex-specific chromatin accessibility and transcription factor binding patterns associated with nociceptive gene regulation.

The paper identifies persistent changes in nociceptor mRNA translation following hyperalgesic priming and shows Gpr88 and Metrn regulate this state.