Author

Sai Luo

Boston Children's HospitalORCID 0000-0002-7362-5445Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Developmental Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Adam Yongxin YeiD· 1 shared Aibin HeiD· 1 shared Fanchong JianiD· 1 shared Fei Shao· 1 shared Fuchou TangiD· 1 shared Haiyan SuniD· 1 shared Hui ZhengiD· 1 shared Jianqiao HuiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperBioinformatics

Adam Yongxin YeORCID

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3 papers

Recent·Most cited

Mouse V(D)J Humanization Recapitulates human-like Severe SARS-CoV-2 Immune Imprinting

Xiao Niu, Fanchong Jian, Yutong Kelly Li, Ke Li, Siyu Lei, Weiliang Song, Rui Kong, X L Cai, Ran An, Yao Wang, Yifei Huang, Lingling Yu, Wenjing Wang, Haiyan Sun, Yuanling Yu, , Yunlong Cao

This study shows that V(D)J-humanized mice can replicate severe SARS-CoV-2 immune imprinting in humans, revealing that pre-existing antibody abundance influences imprinting severity.

bioRxiv · Jun 11, 2026 · PreprintImmunology

TrieDedup: A fast trie-based deduplication algorithm to handle ambiguous bases in high-throughput sequencing

Jianqiao Hu, Sai Luo, Ming Tian, Adam Yongxin Ye

TrieDedup is a trie-based deduplication algorithm that efficiently handles ambiguous bases in high-throughput sequencing by reducing memory usage and increasing speed compared to pairwise comparison methods.

BMC Bioinformatics · Apr 18, 2024Peer-reviewedBioinformatics

The long noncoding RNA Hand2as orchestrates heart development through regulation of precise expression of HAND2

Xue Han, Jiejie Zhang, Yaxi Liu, Xiaoying Fan, Shanshan Ai, Yingjie Luo, Xin Li, Sai Luo, Hui Zheng, Yanzhu Yue, Zai Chang, Zhongzhou Yang, Fuchou Tang, Aibin He, Xiaohua Shen

This study identifies Hand2as as a key lncRNA regulating HAND2 expression in heart development through single-cell RNA sequencing and knockout models, leading to congenital defects and perinatal lethality.

bioRxiv · Nov 26, 2018 · PreprintDevelopmental Biology