3 papers
Karsten D. Householder, Xinyu Xiang, Kevin M. Jude, Arthur Deng, Matthias Obenaus, Yang Zhao, Steven C. Wilson, Xiaojing Tina Chen, Nan Wang, K. Christopher García
A de novo four-helix bundle designed with RFdiffusion and ProteinMPNN binds NY-ESO-1/HLA-A*02 at Kd 9.5 nM, with a 2.05 Å crystal structure and peptide-focused docking.
Science · Jul 24, 2025Peer-reviewedImmunology✦ In-depth digest
Yuhan Hao, Stephanie Hao, Erica Andersen‐Nissen, William M. Mauck, Shiwei Zheng, Andrew Butler, Madeline J. Lee, Aaron J. Wilk, Charlotte A. Darby, Michael A. Zager, Paul Hoffman, Marlon Stoeckius, Efthymia Papalexi, Eleni P. Mimitou, Jaison Jain, , Rahul Satija
Weighted-nearest neighbor (WNN) analysis in Seurat v4 learns per-cell modality weights to define cell states, enabling a 228-antibody human PBMC CITE-seq reference for RNA-only query mapping.
Cell · May 31, 2021Peer-reviewedGenomics✦ In-depth digest
Colin J. B. Harvey, Man‐Cheng Tang, Ulrich Schlecht, Joe Horecka, Curt R. Fischer, Hsiao‐Ching Lin, Jian Li, Brian Naughton, J. Michael Cherry, Molly Miranda, Yong Fuga Li, Angela M. Chu, James R Hennessy, Gergana A Vandova, Diane O. Inglis, , Maureen E. Hillenmeyer
A yeast-based refactoring platform (HEx) with new inducible promoters, an engineered host strain, and homology-based assembly expressed 41 cryptic fungal gene clusters; 22 yielded non-native compounds.
Science Advances · Apr 11, 2018Peer-reviewedSynthetic Biology✦ In-depth digest