human

This study shows MmuPV1 and HPV16 E6 oncoproteins disrupt NF-κB signaling by increasing nuclear IKKα localization, suggesting a shared mechanism in papillomavirus persistence.

This study identifies a phosphorylation-dependent conformational change in the K19 head domain that affects filament assembly and interactions with GSK3β, but not 14-3-3 proteins.

R2T2P integrates transcriptomics and proteomics data to study FSHD, revealing novel RNAs and their impact on translation and protein levels.

This study shows that older adults exhibit enhanced implicit motor adaptation only with consistent errors, not variable ones, suggesting error consistency is key for age-related adaptation.

This study identifies 15 novel tau-interacting proteins through yeast two-hybrid screening and validates their interactions, revealing potential biomarkers and therapeutic targets for neurodegenerative diseases.

This paper develops a PD-1 chimeric switch receptor T-cell platform that improves tumor targeting while reducing toxicity to normal cells in PD-L1-targeted therapies.

This study shows that therapeutic anti-IgE antibodies form immune complexes with distinct functional properties, influenced by allergen incorporation and receptor binding patterns.

This study shows that oral exposure to 1,2-propanediol increases exhaled propanal and 1-propanol, suggesting microbial conversion in the mouth.

This study shows ATF3 helps macrophages manage cholesterol during metabolic stress by balancing inflammation and sterol-responsive gene expression.

This study identifies host factors and cellular contexts governing anellovirus persistence through genomic, transcriptomic, and functional analyses.

The paper introduces MaaD-TAD, an all-atom model of a duplicated chromatin domain, using sequence homology and cohesin placement to reconstruct DNA structure where Hi-C data are missing.

MorphoANOVA systematically analyzes spatial gene-expression patterns in relation to tissue morphology, identifying genes with location-specific associations and spatial expression beyond morphology.

This study investigates age-related changes in protein insolubility in skeletal muscle and shows that these changes are sex- and compartment-specific and can be modified by exercise and rapamycin.

This study quantifies single-cell contractility in human trabecular meshwork cells under various conditions and finds that contractility is context-dependent, shaped by both extracellular and intracellular factors.

This study benchmarks foundation models for resting-state fMRI time series in cognitive aging, finding mixed results on their utility for cognitive assessment and prediction.

This paper introduces a covariate-dependent hidden semi-Markov model to analyze brain network state durations, finding that age and sex influence dwell times in specific brain states.

The paper identifies a ciliogenesis-primed secretory cell state preferentially infected by seasonal H1N1 IAV in human airway epithelium.

This study examines circulating CD4 regulatory T cells in Parkinson's disease and finds they are largely preserved in phenotype and function, though show reduced HELIOS expression in naive subsets.

This paper introduces a variant filtering framework called SMART filtering to improve diagnostic outcomes in genome sequencing by prioritizing non-coding and regulatory variants.

This paper develops a framework to engineer oncolytic vaccinia virus to support off-the-shelf NK cells by aligning viral payloads with NK cell manufacturing limitations.

This paper introduces SHARP, a method using cosmological web analysis to characterize brain ageing and cognitive impairment by analyzing MRI data from CamCAN and OASIS-3.

This study evaluates AlphaGenome's ability to predict gene expression changes after promoter perturbations, finding discrepancies between CAGE and RNA-sequencing predictions.

This study shows STMN2 regulates microtubule dynamics and axonal resilience in human motor neurons, linking cytoskeletal homeostasis to ALS pathology.

DIALECT enables synthetic cells to communicate with mammalian cells via DNA-programmed ligand release and engineered receptors, achieving specific signaling and logic gate functions.

TriStageHLA improves epitope prioritization by integrating peptide screening, binding prediction, and immunogenicity assessment with high accuracy and efficiency.

The paper identifies a PTN-rich MSC subtype that enhances cartilage repair in KOA by modulating key inflammatory and repair pathways.

The paper investigates network competition in the brain using electrophysiology and neuroimaging, finding temporally layered antagonism between default and task-related networks, with distinct patterns in the hippocampus.

This paper introduces π-SPECFormer, a foundation model for mass spectrometry-based proteomics that decodes the dark proteome by pre-training on unannotated spectra and outperforms baselines in peptide sequencing and modification detection.