mouse

This study shows BNCT reduces B16 melanoma growth and survival, induces immunogenic cell death and a Th1 response, but fails to increase CD8+ T-cell infiltration, suggesting immune resistance mechanisms may limit its efficacy.

This study uses compartment-resolved proteomics to analyze changes in the tendon matrisome during postnatal maturation in mice, revealing distinct trajectories in soluble and insoluble ECM components.

The paper shows that simple nonlinearities in the visual cortex can explain complex interactions between visual, motor, and cognitive variables through additive input modulation.

The paper identifies clonally convergent Tfh/Tph-like CD4+ T cells that persist in the mucosa after recovery from periodontitis and contribute to recurrence.

This study identifies ferroptosis in embryonic lung and kidney progenitor cells, showing its role in organ morphogenesis through genetic manipulation of Gpx4.

This study shows that Pgm2 in Pneumocystis links glucose-phosphate metabolism to β-1,3-glucan synthesis and cell-wall integrity, making it a potential antifungal target.

This study shows BCL10 gain-of-function mutations prevent naive B cells from entering germinal centers and cooperate with BCL6 to cause extrafollicular diffuse large B-cell lymphoma.

This study examines how captivity and cross-fostering affect gut microbiota in wood mice, finding that microbial diversity and functional potential shift with host history and environment.

The paper identifies sex-specific transcriptional differences in specific cell types of the human subgenual anterior cingulate cortex and links them to GPCR signaling differences in mice.

This study examines neural responses in mouse visual cortex to natural and artificial visual stimuli, finding increased activity in response to natural mismatches but no change in dendritic-somatic coupling.

MorphoProt predicts spatial protein abundance using RNA expression, multiscale histology, and tissue neighborhoods, outperforming baselines in human and mouse tissues.

The paper assesses the transportability of mouse gene knockout models to human complex phenotypes using GPAT framework, finding evidence for 12 phenotypes but limited for others.

ClearGel enables chronic, near-millimeter two-photon imaging through the intact skull in live mice with high resolution and reversibility.

The paper introduces the Spectral Complexity Index (SCI), a white-box measure of single-neuron computational complexity that outperforms existing methods in efficiency and interpretability.

This paper describes a workflow for dual-guide CRISPR-Cas9 editing of Pla2g6 in mouse BMDMs, showing high editing efficiency and specific deletion patterns.

This study examines how Clcn7 mutations in mice affect bone phenotypes, showing increased trabecular bone mass with variations based on age, sex, genetic background, and mutation type.

This study shows that physiological caffeine doses do not impair enteric neural crest cell migration in a mouse model, suggesting caffeine is not directly responsible for Hirschsprung disease risk.

This study optimizes a subcutaneous xenograft model for EHE using patient-derived cells, showing that low cell densities produce reproducible tumors sensitive to mTOR inhibition.

The paper identifies PICJIs as large mobile genetic elements in E. coli and Salmonella that spread antimicrobial resistance and defense systems via a specific bacteriophage.

This study identifies age-acquired enhancers in mouse hearts and shows that exercise can reverse their activation.

This study shows that postnatal Cajal-Retzius cells are crucial for stabilizing hippocampal spatial representations and adaptive behavior.

This study shows IL-23 promotes the transition from preclinical autoimmunity to arthritis by enhancing IL-17A and IFN-gamma production, and identifies IL-23 pathway changes in at-risk individuals.

This study shows chronic sleep disruption causes distinct transcriptional and proteomic changes in brain compartments, particularly affecting synaptic function and potentially contributing to Alzheimer's risk.

SQANTI-evidence annotates genomes from long-read RNA-seq without a reference, achieving high precision in gene and isoform prediction across species.

The paper identifies a rare population of neural crest-derived endocardial cells essential for heart valve development in mice and humans, showing their role in valve morphogenesis through Pthlh signaling.

This study identifies Mif as an oocyte-stored protein that promotes preimplantation embryo development through extracellular signaling, showing its role in blastocyst growth and density-dependent effects.

The paper identifies CD90 as a marker distinguishing two muscle stem cell subpopulations with different activation kinetics and quiescence maintenance mechanisms in mice and humans.

The paper shows that neural populations adjust their optimal temporal resolution during stimulus processing, becoming faster and more nonlinear when decoding information is most accurate.