cell signaling & trafficking

This paper shows that mitochondrial dysfunction triggers a translational stress response via GCN2 kinase, leading to diabetic pain, and demonstrates interventions to block this pathway.

The paper identifies EveD, a rhizobial protein in EVs that affects nodule competitiveness and genotype-specific symbiotic responses in legumes.

This study identifies RPLP1 ribosome remodeling under glucotoxic conditions as a mechanism impairing beta-cell function and insulin secretion in diabetes.

This study identifies a PI3K-RAC1 signaling axis that promotes endothelial dysfunction in TIE2-mutated venous malformations by enhancing migration and vascular lumen size.

The paper investigates how transcription factor handover between Notch and Broad regulates the temporal progression of gene expression through dynamic hub formation.

This study shows that genome polarization is essential for Rickettsia parkeri's fitness, as disrupting polar proteins causes cell division defects and reduced host cell spread.

This study identifies Contact-phagy as a selective autophagy pathway that targets ER-mitochondria contact sites for turnover under metabolic and mitochondrial stress.

This study uncovers distinct roles of RIAM and Lpd in osteoclast fusion and resorption through differential Rap1-Talin1 signaling, showing that disrupting the direct Rap1-Talin1 interaction reduces bone resorption and increases bone mass.

This study shows that blocking CR2/CD21 on both B cells and follicular dendritic cells reduces GC activity and autoimmunity in lupus by synergistically inhibiting B cell responses and reshaping immunological memory.

This study shows dietary HSP90 extends C. elegans lifespan and healthspan via extracellular signaling, and combines it with a senolytic inhibitor for enhanced longevity.

The paper develops a C. elegans model to visualize subcellular architecture across adult life and identifies a midlife architectural state shift linked to aging and homeostatic challenges.

This study shows that hypoxia and reoxygenation drive distinct phases of intestinal epithelial damage and repair in Drosophila, with coordinated apoptosis and ISC proliferation required for recovery.

This study identifies RAC1P29S and MERTK as drivers of melanoma cell cannibalism of T cells through a 'grip and gulp' mechanism involving actin dynamics.

This paper introduces Octomod, a workflow using large language models to aid in mechanistic model construction and refinement in systems biology, demonstrating its effectiveness across multiple applications.

This paper develops a luciferase reporter system to measure ester prodrug delivery and hydrolysis in mycobacteria, showing that permeation and intracellular unmasking depend on chain length and branching, respectively.

The paper investigates IFT-A-IFT-B coordination in cilia using multiple techniques and finds that BBSome-IFT proximities are essential for their coupling.

The paper identifies a metastable GαS/β-arrestin complex in endosomes that sustains PTH1R signaling and cAMP production, offering new insights for drug development.

This paper introduces HUH-tag conjugation for site-specific protein functionalization of DNA origami, enabling efficient and cost-effective signaling-competent protein attachment.

The paper identifies a molecular switch in endothelial cells driven by VEGF-A that modulates RNA stability through Phf6 phosphorylation to coordinate angiogenesis.

This study identifies phosphoproteome remodeling in diatoms under P limitation and resupply, revealing a P-sparing strategy and mechanisms for rapid recovery.

The paper shows that integrin-expressing cells can take up latent TGF-β1 via trogocytosis, convert it into an active signaling molecule, and relay signals to bystander cells.

The paper investigates the distinct roles of Atg3 and Atg10 in autophagosome formation in yeast, showing Atg3 affects lipidation and size while Atg10 controls number.

The paper identifies ROR1 activation as a key pathway mediating the protective effects of NMDAR antagonists on pancreatic islet cells through phosphoproteomics and kinase profiling.

This study shows that Rab7 activation improves lysosomal dynamics and mitophagic flux in iron overload, enhancing mitochondrial function and cell survival.

The paper identifies a short nucleophosmin isoform that links nucleolar remodeling to DNA damage repair during meiosis by interacting with γH2AX.

This paper develops a method to sustain Tie2 activation using engineered mRNA, showing improved endothelial stabilization compared to traditional ligands.

This paper introduces xGL-APMS to profile endogenous galectin-3 interactions at the cell surface, identifying 125 interactors on Jurkat cells and 69 on mouse thymocytes.

This study shows PKR inhibition reduces apoptosis in DYT-PRKRA cells by blocking CHOP induction, suggesting it as a potential therapy for this dystonia.

The paper shows that Wnt proteins, receptors, and Dvl localize asymmetrically in C. elegans seam cells, linking Wnt gradients to cell polarity through positive feedback.

This study shows a dynamin mutation causes neuropathy-like phenotypes by affecting microtubule stabilization through Patronin/CAMSAP interaction in Drosophila and mammalian cells.