transcription & RNA processing

This study shows that endocytosis enhances cAMP signaling and promotes gluconeogenic gene transcription via the glucagon receptor in hepatocytes.

This paper introduces a new Arabidopsis transcriptome dataset with improved accuracy and resolution using novel Iso-seq analysis methods, enhancing transcript expression and splicing analysis.

The paper identifies a nucleo-adhesome, showing that adhesion proteins localize to the nucleus and regulate transcription through interactions like FAK and Hic-5.

This paper identifies a transient metabolic and transcriptional phase in ETEC before stationary phase, marked by shifts in amino acid metabolism and neurotransmitter precursor degradation.

This study shows that the transcriptional response to oxidative stress in Drosophila cells occurs independently of stress granule formation.

The paper identifies primate-specific transposable elements and their regulatory factors that influence transcriptional networks during human development.

This study identifies NSUN6 as an RNA methyltransferase that regulates glioblastoma response to temozolomide through 5mC-mediated control of NELFB and RPS6KB2.

The paper manipulates DNA supercoiling in Synechocystis sp. PCC 6803 using CRISPRi and TopoI overexpression, revealing its role in diurnal gene regulation and growth.

This study demonstrates the use of alginate microgels as a support bath for aspiration-assisted freeform bioprinting of hMSC spheroids, achieving high fusion efficiency and positional accuracy for bone tissue fabrication.

The paper identifies a translation-dependent silencing mechanism in Arabidopsis that suppresses an invasive transposon by generating sRNAs from a subgenomic mRNA.

The paper investigates how a three-dimensional pre-mRNA structural scaffold influences spliceosomal component recruitment beyond traditional splice signals.

This study identifies PARP7's zinc finger domain as critical for its nuclear localization and ability to ADP-ribosylate the agonist conformation of the androgen receptor, influencing AR-dependent transcription.

The paper investigates how APRIL signaling promotes plasma cell longevity by activating multiple transcriptional programs in human plasmablasts.

The paper uses single-nucleus RNA-Seq to analyze cell diversity and transcriptome evolution in Drosophila accessory gland and ejaculatory duct tissues across species.

The paper uses whole transcriptome sequencing to show that mitochondrial complex I genes are completely lost in mistletoes and that mitochondrial transcripts are polyadenylated.

This study examines the distribution of transcriptional outputs in Myc-amplified medulloblastoma cells and identifies IMPDHs as a therapeutic target.

This study identifies unique nuclear import and chromatin engagement mechanisms of AR-V7 in castrate-resistant prostate cancer, suggesting a Hit-and-Run transcriptional mode.

This study identifies NtMED25 as a mediator subunit that interacts with NtMYC2s to regulate nicotine biosynthesis in Nicotiana tabacum by enhancing gene expression.

This study identifies a p53-like transcription activation domain in PIF3 and shows that PHYB binding inhibits its activity, revealing a photoresponsive transcriptional switch in Arabidopsis.

This study examines the population dynamics and transcriptional features of endophytic bacteria in plant leaves, finding they maintain stable populations through a balance of growth and death, with transcriptomic profiles resembling stationary phase bacteria.

The paper identifies ESB1 as a stage-specific activator required for monoallelic VSG transcription in Trypanosoma brucei, revealing its role in Pol I recruitment to the expression site body.

This paper shows CTCF regulates HPV18 transcript splicing and late gene expression during differentiation by controlling chromatin looping and splice site usage.

This study shows caveolae deformation affects protein levels and cytosolic RNA, impacting stress granule formation through cavin-1 relocalization.

This study uses long-read sequencing to show DNA methylation affects pre-mRNA splicing, poly(A) tail length, and gene silencing in Arabidopsis.

This study identifies the molecular mechanism by which eRNAs stimulate Pol II pause release by interacting with NELF through unpaired guanosines.

The paper examines how ammonium nutrition alters the epitranscriptome in maritime pine roots, showing m6A modifications regulate translation and proteome responses.

This paper develops fibrous hydrogel assemblies that contract when encapsulated with mesenchymal stromal cells, enabling programmed shape changes for biofabrication and tissue engineering.

The paper uses RNA imaging in live Arabidopsis plants to study single-cell transcriptional dynamics, finding rapid transcriptional repression in response to phosphate and high intrinsic noise.

The paper investigates how RNA-binding proteins (RBPs) influence RNA polymerase II activity through phase separation, showing that RBPs like PSPC1 enhance polymerase engagement and transcription.