Schizophrenia research and treatment

Ultra-rare coding variants in schizophrenia risk genes are associated with longitudinal phenotypic differences across psychotic disorders

This study identifies ultra-rare damaging variants in schizophrenia risk genes and shows they are associated with earlier hospitalizations, greater childhood adversity, and poorer neuropsychological outcomes across psychotic disorders.

Environmental risk reshapes high-confidence schizophrenia risk genes during a developmental window of vulnerability

The paper investigates how early-life stress alters the expression of schizophrenia risk genes in mice during development, identifying region- and cell-type-specific effects.

Adolescent prodromal phenotypes of psychiatric disorders: insights from a novel DISC1-perturbed monkey model

This paper presents a novel monkey model with impaired DISC1 gene to study adolescent prodromal phenotypes of psychiatric disorders, finding altered social behavior and disrupted brain connectivity.

Dissection of neuropsychiatric-relevant behavioral and structural phenotypes utilizing neuron type-specific ablation of the Bassoon gene in mice

This study investigates the effects of Bassoon gene ablation in specific mouse neuron populations on behavioral and structural phenotypes resembling schizophrenia.

Virtual Brain Modelling Reveals Altered Network Dynamics and Predicts Symptom Severity in Schizophrenia: Relevance to Antipsychotic Treatment Response and Resistance.

The paper uses virtual brain modelling to identify network-specific alterations in excitation/inhibition profiles in treatment-resistant schizophrenia and links them to symptom severity.

Transcriptomic reconstruction of an interregional molecular connectome in schizophrenia

The paper constructs an interregional molecular connectome in schizophrenia using transcriptomic data and identifies candidate dysregulations in neural circuits.