Tuberculosis Research and Epidemiology

Gene expression models based on a reference laboratory strain are bad predictors of Mycobacterium tuberculosis complex transcriptional diversity.

The paper shows that gene expression models based on the H37Rv strain poorly predict transcriptional diversity in Mycobacterium tuberculosis complex strains.

Two parallel pathways implement robust propionate catabolism and detoxification in mycobacteria

The paper characterizes two propionate catabolism pathways in mycobacteria, showing the methylcitrate pathway's high capacity and the methylmalonyl pathway's detoxification role.

Modeling the Structural Origins of Drug Resistance to Isoniazid via key Mutations in Mycobacterium tuberculosis Catalase-Peroxidase, KatG

This study analyzes 14 novel mutations in M. tuberculosis KatG using structural models to identify how they restrict access channels to the catalytic heme, potentially causing isoniazid resistance.

Predicting susceptibility to tuberculosis based on gene expression profiling in dendritic cells

The paper uses gene expression in dendritic cells to predict tuberculosis susceptibility, finding differentially expressed genes and genetic polymorphisms associated with TB risk.

Updated reference genome sequence and annotation of Mycobacterium bovis AF2122/97

The paper updates the reference genome of Mycobacterium bovis AF2122/97 with new annotations, corrected SNPs, and confirms the presence of the RD900 locus.

Structural basis of Mycobacterium tuberculosis transcription and transcription inhibition

This study reports crystal structures of Mycobacterium tuberculosis RNA polymerase with and without antituberculosis drugs, revealing a new class of inhibitors and their binding mechanisms.