Hepatitis B Virus Studies

The paper determines the cryo-EM structure of bulevirtide bound to NTCP, revealing its mechanism of inhibiting HBV/HDV entry and providing insights for drug development.

This study shows that ALKBH5, an N6-methyladenosine demethylase, regulates HBV and host gene expression under hypoxic conditions by affecting viral transcript stability.

This study uses multi-view modelling to improve prediction of HBV vaccine response by integrating bulk RNA-seq, T-cell data, flow cytometry, and clinical metadata.

This study uses random forest analysis to identify amino acid sites in HBV genome that predict genotype, finding 10 key sites across four genes with implications for HBV evolution and spacer domain function.

This paper integrates clinical data and scientific literature to identify HBV mutations associated with drug resistance and highlights a common mutational position in the entecavir binding pocket.

DeepHBV is a deep learning model that predicts HBV integration sites using genomic features, showing improved performance with additional data and revealing key transcription factor binding sites.

The paper models HBV kinetics in humanized mice treated with interferon-alpha, lamivudine, or both, revealing biphasic viral decline and distinct treatment effects on HBV DNA synthesis.

The paper shows that IFN-γ/Stat1-induced PD-L1 suppresses anti-HBV T cell responses, and blocking PD-L1/PD-1 improves HBV clearance in mice.

This paper describes a method to generate full-length HBV genome data using isothermal amplification and sequencing with Nanopore and Illumina, achieving high consensus accuracy and resolving intra-sample variants.

This study shows that a nonsense mutant of HBV LHBs protein interacts with Jab1 to downregulate tumor suppressors p53 and Smad4, promoting HCC development.

The paper identifies a novel HDV-like agent in ducks, showing genetic divergence but structural and functional similarities to HDV, challenging current understanding of HDV origins.

This study uses exome sequencing to investigate genetic factors contributing to acute liver failure from HBV infection in liver transplant recipients but finds no causal variants.