Hepatitis B Virus Studies

Time-resolved proteomic analysis of hepatitis B virus infection

This study uses time-resolved proteomics to analyze host protein changes during early HBV infection, revealing coordinated proteome alterations and specific complement pathway dynamics.

Promyelocytic leukemia (PML) suppresses hepatitis B virus cccDNA transcription through SUMOylation- and SMC5/6-dependent mechanisms

This study shows PML suppresses HBV cccDNA transcription via SUMOylation and SMC5/6-dependent mechanisms, with HBx modulating this interaction.

Genetic accessibility, not superior fitness, determines which anti-HBs antibody escape variants are selected in patients

This study identifies that genetic accessibility, not superior fitness, determines the selection of anti-HBs antibody escape variants in patients using in vivo screening.

Serum IgM crosslinks hepatitis B subviral particles into supramolecular immune complexes

The paper uses cryo-ET to show serum IgM crosslinks HBV SVPs into supramolecular immune complexes through multivalent Fab interactions.

The HBV basal core promoter mutation confers a replicative advantage and transcriptionally reprograms hepatocytes toward HCC subtypes

This study shows that HBV BCP mutations enhance viral replication and alter hepatocyte transcription, linking to specific HCC subtypes.

Residue-level predictions of the protein-protein interactions of the hepatitis B virus core and envelope proteins

The paper predicts residue-level protein-protein interactions between hepatitis B virus core and envelope proteins using deep learning and coevolution signatures, comparing results with experimental data.

Infection of neotropical non-human primates with bat deltaviruses

This study detects deltaviruses in neotropical non-human primates and finds phylogenetic links to vampire bats, suggesting cross-order host shifts and a zoonotic origin for hepatitis D virus.

Precision-cut liver slices as a model for evaluating therapeutic agents against hepatitis B and delta viruses

This study evaluates precision-cut liver slices as an ex vivo model for studying HBV/HDV co-infection and testing antiviral agents.

Vorapaxar and aripiprazole suppress hepatitis B virus replication through distinct host signaling pathways

This paper identifies vorapaxar and aripiprazole as inhibitors of HBV replication through distinct host signaling pathways, showing their potential as host-targeting antivirals.

E3 ubiquitin ligase HUWE1 mediates K6-linked polyubiquitylation and stabilization of Nrf2 to restrict hepatitis B virus replication

Therapeutic Potential of the Novel Monoclonal Antibody 7-4G against HBsAg in a Mouse Model of Chronic Hepatitis B Virus Infection

This study evaluates the antiviral activity of the monoclonal antibody 7-4G against HBsAg in a mouse model of chronic HBV infection, showing significant reduction in viral markers.

Orthogonal CRISPR screens and human liver chimeric mice identify hepatitis B virus host factors

The paper identifies HBV host factors using CRISPR screens and human liver chimeric mice, finding that EXOC1 is antiviral and ZCCHC14 is proviral.

PML nuclear bodies orchestrate the storage and degradation of aggregated HBc in the nucleus and reduce CAM-A-induced apoptosis.

This study shows that PML nuclear bodies store and degrade aggregated HBc, reducing apoptosis caused by CAM-A.

CD8 T cells with classical and NK-like cytotoxic gene expression programs mediate control of HBV replication and functional cure

The paper identifies two distinct CD8 T cell gene expression programs in HBV infection that correlate with viral control and functional cure.

Hepatitis B virus protein X promotes hepatocyte plasticity and survival in a differentiated human liver organoid system

This paper shows HBx promotes hepatocyte survival and reduces differentiation in human liver organoids, potentially contributing to liver cancer.

Reversal effects of Isochlorogenic acid A on HBV-induced transcriptional dysregulation and apoptotic signaling

This study investigates how ICAA affects HBV-induced gene expression and apoptotic signaling in HepAD38 cells, finding it reverses transcriptional dysregulation and promotes apoptosis.

Reconciling fast Hepatitis B evolutionary rates with ancient co-divergence

This study uses a Bayesian mixed-effects molecular clock model to analyze HBV genomic data, revealing declining evolutionary rates and linking viral spread to human migration patterns.

Preserved CD4+ T cell helper function and coordinated antiviral immunity in people with HBV/HIV co-infection on long-term therapy

This study shows that people with HBV/HIV co-infection maintain functional HBV-specific CD4+ T helper responses and coordinated CD4/CD8 antiviral immunity, suggesting preserved antiviral immunity.

Preclinical antiviral study of a liver-targeted TLR1/2 agonist in an immune-competent mouse model of HBV infection

This study evaluates a liver-targeted TLR1/2 agonist nanoparticle formulation for HBV treatment, showing enhanced antiviral effects compared to free agonist in mice.

Modeling Reveals How Direct-Acting Antivirals Redirect HBV Capsid Assembly Pathways to Noninfectious Products

The paper uses a kinetic Monte Carlo model to simulate how CAMs alter HBV capsid assembly, revealing mechanisms that lead to noninfectious structures.

Assembly-active and -inactive forms of HBV capsid protein provide distinctly different binding sites for capsid assembly modulators

This study compares the binding of CAMs to two forms of HBV capsid protein, showing structural differences in CAM site adaptation between assembly-active and -inactive forms.

Snake Kolmiovirus Encodes a Single Form of Delta Antigen and Shows No Evidence of Translation from Open Reading Frame 2

This study investigates the protein expression of Swiss snake colony virus 1 (SwSCV-1) and finds it encodes only a single form of the delta antigen, unlike hepatitis D virus (HDV), and the additional ORF2 does not produce a functional protein.

Spiperone targets HBV cccDNA via ER stress induced innate immune activation and epigenetic silencing

This study identifies Spiperone as a repurposed drug that reduces HBV cccDNA through ER stress and epigenetic mechanisms, showing synergistic effects with tenofovir.

Evaluation of a multiplexed tiling PCR scheme for whole-genome amplification of hepatitis B virus using Oxford Nanopore sequencing

The paper evaluates a tiling PCR primer scheme for HBV whole-genome amplification using Oxford Nanopore sequencing, finding uneven amplicon performance limits full-genome recovery.

Ritonavir-Induced Cellular Stress Alters Viral HBs Glycoprotein Biogenesis and Production of Infectious Hepatitis D Virions

This paper shows ritonavir and other cytochrome P450 inhibitors reduce infectious HDV virion production by inducing oxidative stress and disrupting HBs glycoprotein biogenesis in human hepatocytes.

Identification of molecular determinants governing KIF4 cargo recognition of NTCP and their role in HBV/HDV infection

The paper identifies a leucine-rich motif in NTCP essential for KIF4-mediated trafficking and HBV/HDV infection, revealing a conserved cargo recognition mechanism shared with integrin β1.

Adenine Base Editing Potently Suppresses Hepatitis B Surface Antigen Expression and Inhibits Hepatitis D Virus Release

This study uses adenine base editing to target HBV DNA and suppress HBsAg production and HDV release in vitro and in vivo.

Disruption of the NTCP-EGFR receptor complex as a strategy for selective inhibition of hepatitis B and D virus entry

This study identifies Oxy229, a compound that disrupts the NTCP-EGFR receptor complex, selectively inhibiting HBV and HDV entry without affecting NTCP or EGFR physiological functions.

PreS1-decorated recombinant adenovirus encoding HBV antigens generates neutralizing humoral and cellular immunity

This study develops a vaccine using PreS1-decorated adenovirus that induces neutralizing antibodies and T-cell responses against HBV and HDV.

DNA synthesis inside the hepatitis B virus creates a high-energy spool

The paper determines the structures of mature HBV and Duck HBV, revealing that DNA forms a spool within the capsid that interacts with interior charges and creates a metastable state for genome uncoating.