Stroke Rehabilitation and Recovery

Imaging biomarkers for primary motor outcome after stroke - should we include information from beyond the primary motor system?

The paper assesses whether lesion information beyond the primary motor system can predict motor outcomes after stroke, finding that such information improves prediction even when the biomarker is based on corticospinal tract damage.

Experimental and computational study on motor control and recovery after stroke: towards a constructive loop betweenexperimental and virtual embodiedneuroscience

This study integrates experimental and computational models of motor control and recovery after stroke to improve experimental design through continuous data integration and simulation.

Post-acute administration of the GABAA α5 antagonist S44819 promotes recovery of peripheral limb fine motor skills after permanent distal middle cerebral artery occlusion in rats

This study shows that post-acute administration of S44819 at 10 mg/kg improves skilled forelimb movement recovery in rats after stroke, with effects lasting after drug washout.

Task Related Neural Activity Following Primary Motor Cortical Ischemic Injury in Rats

This study examines how task-related neural activity in spared motor areas of rats correlates with motor recovery after an ischemic injury to the primary motor cortex.

Predictors of arm non-use in chronic stroke: a preliminary investigation

This study identifies predictors of arm non-use in chronic stroke patients, finding that attention/arousal and self-efficacy, along with motor impairment, predict non-use behavior.

A data-driven framework for the selection and validation of digital health metrics: use-case in neurological sensorimotor impairments

The paper introduces a framework to select and validate digital health metrics for assessing sensorimotor impairments using the Virtual Peg Insertion Test, showing its feasibility and validity in neurological patients.

Restoration of motor-evoked cortical activity is a distinguishing feature of the most effective rehabilitation therapy after stroke

This study identifies that combined optogenetic stimulation and motor training restores pre-stroke motor-evoked cortical activity, distinguishing it as the most effective post-stroke rehabilitation therapy.

Direction of gait asymmetry following stroke determines acute response to locomotor task

The paper examines how different gait asymmetry patterns respond to various locomotor task conditions after stroke, finding differential effects suggesting tailored interventions may be needed.

Relationship Between Motor Capacity of the Contralesional and Ipsilesional Hand Depends on the Side of Stroke

This study finds that the relationship between contralesional and ipsilesional motor capacities differs based on stroke side, with stronger correlations in left hemisphere damage.

Effects of arm weight support on neuromuscular activation during reaching in chronic stroke patients

This study examines how different levels of arm weight support affect muscle activity, synergies, and corticomotor excitability in chronic stroke patients and healthy controls.

Cortical changes in motor preparation facilitate changes in motor execution following an intervention in severe chronic hemiparetic stroke

This study shows that an intervention reduces ipsilesional M1 coupling to contralesional M1 during motor preparation and alters activity in contralesional M1 during execution in chronic stroke patients.

A Cortico- Basal Ganglia Model for choosing an optimal rehabilitation strategy in Hemiparetic Stroke

This paper develops a cortico-basal ganglia model to simulate reaching tasks in stroke patients and evaluates therapy effectiveness based on lesion size.

Rehabilitation promotes the recovery of structural and functional features of healthy neuronal networks after stroke

Lower Extremity Long-Latency Reflexes Differentiate Walking Function After Stroke

This study identifies lower extremity long-latency reflexes as a neurophysiologic marker that differentiates walking function and recovery potential after stroke.

Physiotherapist confidence level in mobilising stroke patients after decompressive hemicraniectomy: are helmets useful?

The paper surveys physiotherapists' confidence in mobilizing stroke patients with skull defects, finding helmets increase comfort for both specialists and non-specialists.

Adopting Literature-based Discovery on Rehabilitation Therapy Repositioning for Stroke

This paper uses the ABC model of literature-based discovery to identify a rehabilitation therapy, HABIT, for stroke, which shows clinical improvement in upper limb function.

Stroke survivors show task-dependent modulation of motor variability during bimanual coordination

This study shows that stroke survivors can modulate motor variability in both affected and unaffected arms based on task demands during bimanual coordination.

Recovery after stroke: not so proportional after all?

The paper challenges the proportional recovery rule by showing that baseline score correlations can mislead about outcome predictability in stroke recovery.

Predicting response to motor therapy in chronic stroke patients using Machine Learning

This study uses machine learning to predict motor improvement in chronic stroke patients after therapy, finding that pre-intervention assessments and motor thresholds are key predictors.

Biomarker-based patient selection improves stroke rehabilitation trial efficiency

This paper shows that using motor evoked potential (MEP) status to select stroke patients improves trial efficiency by reducing sample size and recruitment time.

Revealing an extended critical window of recovery post-stroke

This study uses a meta-analysis to show that VR-based rehabilitation for upper extremities in stroke patients remains effective beyond the traditional 3-6 month critical recovery window, extending over a year.

Power spectrum slope and motor function recovery after focal cerebral ischemia in the rat

This study examines EEG power spectrum slope and its correlation with motor function recovery in rats after focal cerebral ischemia.

Corticospinal neuroplasticity and sensorimotor recovery in rats treated by infusion of neurotrophin-3 into disabled forelimb muscles started 24 h after stroke

This study shows that delayed peripheral infusion of neurotrophin-3 improves sensorimotor recovery after ischemic stroke in rats by inducing spinal neuroplasticity.

Brain-Computer Interfaces for Post-Stroke Motor Rehabilitation: A Meta-Analysis

This paper conducts a meta-analysis of BCI-based post-stroke motor rehabilitation, finding a medium to large effect size on motor improvement.

Lempel-Ziv complexity of the EEG predicts long-term functional recovery after stroke in rats

This study uses Lempel-Ziv complexity analysis to predict long-term motor recovery after stroke in rats, finding that LZC asymmetry correlates with recovery outcomes.

Rehabilitation promotes the recovery of functional and structural features of healthy neuronal networks after stoke

This study shows rehabilitation promotes recovery of both structural and functional features of healthy neuronal networks after stroke in mice.

Finger recruitment patterns during mirror movements suggest two systems for hand recovery after stroke

The paper analyzes mirror movements in stroke patients to assess contributions from cortical and subcortical pathways to hand recovery.

Reward and punishment enhance motor adaptation in stroke

This study shows reward and punishment enhance motor adaptation and retention in stroke patients, similar to healthy controls.

Recovery of hand function after stroke: separable systems for finger strength and control

This study tracks recovery of hand function after stroke, finding that strength and finger control recover differently, with individuation improving beyond a strength threshold due to CST-dependent mechanisms.