Acute Kidney Injury Research

Shared and Specific miRNA-mRNA in Human and Murine Acute Kidney Injury

The paper compares miRNA-mRNA profiles across human and murine AKI models to identify shared and specific molecular programs associated with different injury etiologies and biological heterogeneity.

AVPR2 antagonism with tolvaptan alters medullary cell responses and attenuates kidney injury

This study shows that Tolvaptan reduces medullary cell stress and inflammation in kidney injury models.

Dynamics of cell states and alternative splicing following kidney ischemia-reperfusion injury

The paper analyzes bulk RNA-seq data from a kidney IRI mouse experiment to identify temporal phases and alternatively spliced genes, revealing potential splicing regulators involved in injury and repair.

A synchronization modulation electric field reduces early ischemic kidney injury in pigs and suppresses a stress and inflammatory program without detectable leukocyte accumulation

Macrophage-Derived 25-Hydroxycholesterol Drives Statin-Associated Acute Kidney Injury

This study shows that macrophage-derived 25-hydroxycholesterol increases susceptibility to statin-induced acute kidney injury by impairing autophagy and promoting cell death.

Modified 3rd Generation Synchronization Modulation Electric Field (3m-SMEF) Prevents Ischemia-Reperfusion-Induced Acute Kidney Injury via Targeting Na⁺/K⁺-ATPase

The paper demonstrates that modified 3rd-generation SMEF (3m-SMEF) protects against ischemia-reperfusion-induced AKI by preserving Na/K-ATPase function and tubular integrity in vitro and in vivo.

Cross-species multi-omics integration reveals lung alterations in acute kidney injury across mouse, pig, and human airway organoid models

This paper integrates multi-omics data across species to show AKI-induced lung alterations, identifying conserved pathways and human-validated targets for distant organ failure.

To Recover or Not to Recover: A Urinary Proteomic Perspective on Severe Acute Kidney Injury

This study evaluates a urinary FABP3/APOA1 ratio as a predictor of renal recovery after severe AKI, showing high accuracy in both discovery and validation cohorts.