Acute Kidney Injury Research

Shared and Specific miRNA-mRNA in Human and Murine Acute Kidney Injury

The paper compares miRNA-mRNA profiles across human and murine AKI models to identify shared and specific molecular programs associated with different injury etiologies and biological heterogeneity.

AVPR2 antagonism with tolvaptan alters medullary cell responses and attenuates kidney injury

This study shows that Tolvaptan reduces medullary cell stress and inflammation in kidney injury models.

Dynamics of cell states and alternative splicing following kidney ischemia-reperfusion injury

The paper analyzes bulk RNA-seq data from a kidney IRI mouse experiment to identify temporal phases and alternatively spliced genes, revealing potential splicing regulators involved in injury and repair.

A synchronization modulation electric field reduces early ischemic kidney injury in pigs and suppresses a stress and inflammatory program without detectable leukocyte accumulation

Macrophage-Derived 25-Hydroxycholesterol Drives Statin-Associated Acute Kidney Injury

This study shows that macrophage-derived 25-hydroxycholesterol increases susceptibility to statin-induced acute kidney injury by impairing autophagy and promoting cell death.

Modified 3rd Generation Synchronization Modulation Electric Field (3m-SMEF) Prevents Ischemia-Reperfusion-Induced Acute Kidney Injury via Targeting Na⁺/K⁺-ATPase

The paper demonstrates that modified 3rd-generation SMEF (3m-SMEF) protects against ischemia-reperfusion-induced AKI by preserving Na/K-ATPase function and tubular integrity in vitro and in vivo.

Cross-species multi-omics integration reveals lung alterations in acute kidney injury across mouse, pig, and human airway organoid models

This paper integrates multi-omics data across species to show AKI-induced lung alterations, identifying conserved pathways and human-validated targets for distant organ failure.

To Recover or Not to Recover: A Urinary Proteomic Perspective on Severe Acute Kidney Injury

This study evaluates a urinary FABP3/APOA1 ratio as a predictor of renal recovery after severe AKI, showing high accuracy in both discovery and validation cohorts.

Transient tubular membrane injury is converted into persistent fibrosis through a macrophage-fibroblast relay

This paper identifies a macrophage-fibroblast relay mechanism that converts transient tubular membrane injury into persistent fibrosis following acute kidney injury.

Keto-gluconeogenic metabolic axis mirrors renal homeostasis and post-injury response in spatial transcriptomics

This study identifies a keto-gluconeogenic metabolic axis that mirrors renal homeostasis and injury responses using spatial transcriptomics and biochemical analyses in AKI to CKD transition.

Loss of 20-HETE-GPR75 Signaling Impairs Renal Hemodynamic Adaptation in Sepsis

This study investigates the role of 20-HETE-GPR75 signaling in sepsis-induced renal dysfunction and finds that its loss impairs renal hemodynamics and contributes to acute kidney injury.

HNF4A maintains proximal tubule identity and limits injury-associated cell states in the adult mouse kidney

This study shows that HNF4A maintains proximal tubule identity in adult mouse kidneys and its loss leads to injury-associated gene activation and loss of mature epithelial features.

REN-former prioritizes candidate regulators of kidney disease-state transitions through single-cell foundation modeling and human genetics

REN-former identifies gene regulators of kidney disease transitions by combining single-cell modeling and human genetics.

Prolactin Modulates Renal Ischemia Reperfusion Injury According to Sex and Cathepsin D Genotype

This study shows that Cathepsin D modulates prolactin's effects on renal ischemia reperfusion injury, with sex-dependent outcomes.

SUBCLINICAL ACUTE KIDNEY DISEASE: URINARY PROTEOMIC DIVERGENCE FOLLOWING NEPHROTOXIC AND ISCHAEMIC INJURY

This study identifies urinary proteomic signatures associated with subclinical AKD following nephrotoxic or ischemic injury in rats, revealing persistent structural damage despite functional recovery.

Megalin (LRP2), prenatal betamethasone, and injury susceptibility in the developing kidney

This study evaluates how prenatal betamethasone exposure and tubular maturation affect gentamicin-induced kidney injury and nephron number in rats.

Scalable proxiloids enable human-relevant assessment of kidney proximal tubule toxicity

This study introduces proxiloids, a scalable human-induced pluripotent stem cell differentiation method that models kidney proximal tubule toxicity more accurately than existing methods.

Androgens Drive SOX9 Upregulation in Injured Proximal Tubular Cells

This study shows that SOX9 upregulation in injured proximal tubular cells is driven by androgens in males but blunted in females, revealing sex-specific repair mechanisms in AKI.

Spatial analysis reveals the cellular microenvironments and mechanisms of inflammation and kidney injury in acute interstitial nephritis

The paper identifies the CXCL9-CXCR3 axis and NAMPT as key drivers of inflammation and kidney injury in acute interstitial nephritis using spatial transcriptomics and imaging.

Differentiating Hepatic and Renal Toxicity Reveals CYP-Independent Mechanisms of Acetaminophen-Induced Acute Kidney Injury

This study shows that acetaminophen-induced acute kidney injury occurs through CYP-independent mechanisms, even when hepatic CYP2E1 is deleted, highlighting the need for kidney-specific therapies.

Peripheral CB1R Blockade Suppresses AKI-to-CKD Maladaptive Repair

This study shows that blocking CB1R during kidney repair after AKI prevents CKD by reducing inflammation and metabolic dysregulation.

Spatial metabolomics reveals persistent localized niche-specific metabolic failure in kidneys following ischemia-reperfusion injury

The paper uses spatial metabolomics and transcriptomics to identify persistent metabolic failure in kidney niches after ischemia-reperfusion injury, highlighting mitochondrial dysfunction in otherwise healthy areas.

Integrated Proteo-Metabolomics of Urinary Extracellular Vesicles Reveals Early Molecular Divergence and Temporal Pathogenesis of Sepsis-Associated AKI

This study uses longitudinal proteo-metabolomics of urinary extracellular vesicles to identify stage-specific molecular changes in sepsis-associated AKI, revealing early inflammatory and hypoxic responses followed by metabolic reprogramming.

Population genetics meets precision-cut kidney slices: Nephrotoxicity modelled ex vivo in the founder strains of the BXD mouse consortium

The paper uses precision-cut kidney slices from BXD mouse strains to model nephrotoxicity ex vivo, finding strain-specific differences in susceptibility to drug-induced kidney injury.

ELMO1 dependent efferocytosis protects from nephrotoxin induced acute kidney injury

This study investigates the role of ELMO1 in acute kidney injury, finding that ELMO1 deficiency increases tissue injury in cisplatin-induced AKI but not in ischemia-reperfusion models.

Metabolic Reprogramming Induced by Mitochondrial Citrate Carrier Deletion Mitigates Antibiotics-Induced Acute Tubular Injury

This study shows that deleting the mitochondrial citrate carrier in kidney tubules reduces antibiotic-induced acute tubular injury by altering metabolism and increasing antioxidants.

Targeting Protease-activated Receptor 4 (PAR4) Protects Against Acute Kidney Injury (AKI) in Ischemia Reperfusion Injury

This study shows that PAR4 antagonism reduces AKI severity and improves survival in an IRI mouse model.

Trem2hi macrophages bridge inflammation resolution and fibrosis initiation after ischemia-reperfusion injury in the kidney

This study identifies Trem2hi macrophages as mediators bridging inflammation resolution and fibrosis initiation after kidney injury, showing their role in promoting fibrosis through specific mechanisms.

Chronic exposure to low-concentration urban PM2.5 accelerates maladaptive repair after ischemic injury via mitochondrial dysfunction and lysosomal stress.

This study shows that chronic low-concentration PM2.5 exposure after ischemic injury accelerates CKD through mitochondrial dysfunction and lysosomal stress, with nicotinamide reversing some effects.

Uromodulin promotes immune zonation and inhibits alternative inflammasome-mediated activation of immune-to-collecting duct inflammatory signaling in early acute kidney injury

This study investigates how Uromodulin affects immune zonation and inflammasome activity in kidney injury, showing it reduces inflammation and immune cell interactions in specific kidney regions.