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Topic · Rehabilitation · Medicine

Wound Healing and Treatments

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

3 papers

Rhomboid protease Rhbdl2 regulates macrophage recruitment and wound regeneration in zebrafish

Saroj Gourkanti, Gayathri Ramakrishnan, Jacqueline Cheung, Taylor J. Schoen, Yazmin Munoz, Rosa M. Chavez, Jan Dohnálek, Katie Martin, Matthew Lovett-Barron, Thomas C. Whisenant, Kvido Střı́šovský, Sonya E. Neal

Loss of the rhomboid protease Rhbdl2 in zebrafish larvae speeds tail fin regrowth after injury, raises macrophage accumulation and Rac2 protein, and Rac2 knockdown reverses both effects.

The Journal of Cell Biology · Aug 18, 2026Peer-reviewedImmunology✦ In-depth digest

Fibroblast response to burn injury in larval zebrafish mirrors developmental maturation and is inhibited by infiltrating neutrophils

Adam J. Horn, Yiran Hou, Jayne M. Squirrell, Alexandra M Fister, Julie Rindy, Veronika Miskolci, Jonathan H. Schrope, Russell Burke, Colin N. Dewey, Kevin W. Eliceiri, Anna Huttenlocher A

Vimentin-driven maturation of col1a1a-positive fibroblasts after larval zebrafish burn parallels fin development, but prolonged neutrophil presence delays fibroblast maturation and organized collagen regrowth.

Development · Jul 17, 2026Peer-reviewedDevelopmental Biology✦ In-depth digest

12/15-Lipoxygenase orchestrates murine wound healing via PPARg-activating oxylipins acting holistically to dampen inflammation.

Christopher P. Thomas, Victoria J. Tyrrell, James J. Burston, Sam R. C. Johnson, Maceler Aldrovandi, Jorge Álvarez-Jarreta, Rossa Inglis, Adam Leonard, Lydia Fice, Jeremie Costales, Antonio Vidal‐Puig, Majd B. Protty, Carol Guy, Robert Andrews, Barbara Szomolay, , Valerie B. O’Donnell

Alox15-deficient mice heal skin punch wounds with excess collagen, low matrix metalloproteinase activity and unresolved inflammatory gene expression; topical physiological 12/15-lipoxygenase oxylipin mixtures reduced collagen and raised collagenase activity.

Proceedings of the National Academy of Sciences · Sep 4, 2025Peer-reviewedPharmacology & Toxicology✦ In-depth digest