Wound Healing and Treatments

Persistent CCL3 expression sustains neutrophil recruitment and contributes to delayed wound healing in advanced age

This study shows that persistent CCL3 expression in aged wounds sustains neutrophil recruitment and delays healing by impairing inflammatory resolution.

Healing cascades and infections in wounds monitored using a wearable sensor of gaseous flux

This paper introduces a wearable sensor that monitors gaseous flux from wounds to detect infections and track healing, showing VOC flux correlates with bacterial growth and provides early infection detection.

De Novo Regeneration of Rete Ridges during Cetacean skin wound healing

This study shows that tight-skinned Frasers Dolphins regenerate complex rete ridges with minimal scarring after large full-thickness wounds, despite high-tension and shear stress environments.

Rhomboid protease Rhbdl2 regulates macrophage recruitment and wound regeneration in zebrafish

Loss of the rhomboid protease Rhbdl2 in zebrafish larvae speeds tail fin regrowth after injury, raises macrophage accumulation and Rac2 protein, and Rac2 knockdown reverses both effects.

Dual lineages of Langerhans cells cooperate to restore the immune barrier after skin injury

The paper identifies two distinct Langerhans cell lineages involved in restoring immune barrier function after skin injury.

Fibroblast response to burn injury in larval zebrafish mirrors developmental maturation and is inhibited by infiltrating neutrophils

Vimentin-driven maturation of col1a1a-positive fibroblasts after larval zebrafish burn parallels fin development, but prolonged neutrophil presence delays fibroblast maturation and organized collagen regrowth.

Transcriptomic Profiling of Diabetic Porcine Wound Healing Model Identifies Key Metabolic, Inflammatory, and Oxidative Stress Pathways

This study uses transcriptomic profiling to identify metabolic, inflammatory, and oxidative stress pathways in diabetic porcine wound healing, supporting the model for therapeutic testing.

Exploring mechanisms of scar-free skin wound healing in adult zebrafish in comparison to mouse

The paper compares scar-free skin wound healing in zebrafish and mice, identifying differences in fibroblast behavior and collagen crosslinking mechanisms.

Wound healing and angiogenic profiling of dermal endothelial cells isolated from people with type 2 diabetes.

This study examines dermal endothelial cells from people with type 2 diabetes, finding they have altered migratory, angiogenic, and gene expression profiles compared to healthy cells.

A Novel Monocyte-derived Antigen Presenting Cell-T regulatory Cell Axis Contributes to Skin Wound healing and is Impaired in Diabetic Mice

Composite biomaterials of polyelectrolyte complex micelle nanoparticles in hyaluronic acid gels enable local, targeted miR-92a inhibition and enhanced angiogenesis in diabetic wound repair

This paper develops a composite biomaterial combining polyelectrolyte complex micelles with hyaluronic acid gels to deliver miR-92a inhibitors, enhancing angiogenesis and accelerating wound healing in diabetic mice.

Enterococcus faecium colonization and persistence in a model of diabetic wound infection

This study uses a diabetic mouse model to show that Enterococcus faecium persists in wounds due to impaired clearance and altered immune responses compared to non-diabetic mice.

Investigation of sterile hydrogels as topical vehicles for APOSEC™, a stressed peripheral blood mononuclear cell secretome for the treatment of poorly healing wounds

This study evaluates a hydrogel-based delivery system for APOSEC™ in wound healing, finding improved release but non-uniform mixing and no significant efficacy difference compared to a benchmark gel.

Diminished and altered cellular senescence response in delayed wound healing of aging

This study shows that aging reduces and alters the senescence response in wound healing, leading to delayed repair due to fewer and less functional senescent cells.

DeepMapper: Attention-Based AutoEncoder for System Identification in Wound Healing and Stage Prediction

This paper proposes a deep learning-based control framework for wound healing that accelerates closure by 17.71% in simulations and 40% in vivo.

Basophils drive the resolution and promote wound healing in adult and aged mice

This study shows basophils promote inflammation resolution and wound healing in both adult and aged mice by driving tissue remodeling and immunoregulatory functions.

Smad7-based biologic targeting epidermis and stroma promotes healing of diabetic wounds in mice and pigs

This study shows that Smad7-based biologic treatment accelerates diabetic wound healing in mice and pigs by targeting keratinocytes and neutrophils, reducing inflammation and promoting tissue repair.

An Engineered Living Material with pro-angiogenic activity inducible by near-infrared light

The paper develops an engineered living material that uses NIR light to release a pro-angiogenic peptide, promoting capillary network formation in endothelial cultures.

A multidisciplinary approach for the study of age-dependent expression patterns in porcine experimental wounds

This study uses a multidisciplinary approach to identify age-dependent expression patterns in porcine experimental wounds to improve objective wound age estimation in forensic cases.

Comparative proteomic analysis of skin wound healing responses to biomaterial treatments identifies key pathways which govern differential regenerative outcomes

This study compares proteomic responses to three biomaterials during wound healing, identifying key pathways that explain differences in regenerative outcomes.

Scaffold-mediated miRNA-155 inhibition promotes regenerative macrophage polarisation leading to anti-inflammatory, angiogenic, and neurogenic responses for wound healing

This paper introduces a miRNA-155 inhibitor-activated scaffold that promotes anti-inflammatory, angiogenic, and neurogenic responses in chronic wounds through macrophage polarisation and nerve regeneration.

Perivascular macrophages convert physical wound signals into rapid vascular responses

The paper shows perivascular macrophages convert osmotic wound signals into vascular responses via the cPla2 pathway and Alox5a lipid.

Engineering an Anaerobic Microenvironment to Empower Hydrogenase-Catalyzed Hydrogen Therapy for Diabetic Wound Healing

This paper develops a hydrogel system that creates an anaerobic microenvironment to enable hydrogenase-catalyzed hydrogen therapy under aerobic conditions, improving diabetic wound healing.

Temporal dynamics of macrophages transcriptional profiles during zebrafish wound healing

This study uses bulk RNA sequencing to analyze zebrafish macrophage transcriptional changes during wound healing, revealing dynamic shifts in functional states over time.

The interplay between stiffness and hyperglycemia on diabetic foot ulcer wound closure

This paper develops a 2D wound closure model to study how diabetic foot ulcer healing is affected by skin stiffness and hyperglycemia, finding that higher stiffness and hyperglycemia slow wound closure.

Fluoxetine Delivery for Wound Treatment Through an Integrated Bioelectronic Device - Pharmacokinetic Parameters and Safety Profile in Swine

This study compares fluoxetine delivery via a bioelectronic device to topical bolus dosing in swine wounds, showing higher tissue concentrations and safety with the device.

A chronic state biostimuli-responsive therapeutic model system: applications to skin tissue repair and regeneration

This paper develops a biocompatible therapeutic model system that detects chronic wound states and releases healing agents conditionally in response to environmental factors like pH and ROS.

In Vitro Wound Simulation: A High-Throughput Device for ScratchAssays

This paper introduces a high-throughput scratch assay device for in vitro wound simulation, demonstrating its ability to create uniform, tunable scratches in neural progenitor cells.

Enterococcus faecalis persists and replicates intracellularly within neutrophils

This study shows Enterococcus faecalis persists and replicates intracellularly within neutrophils, prolonging infection and inflammation in chronic wounds.

Thrombin-preconditioned Mesenchymal Stem Cell-Derived Exosomes For Wound Healing in vitro and in vivo

This study shows that thrombin-preconditioned mesenchymal stem cell-derived exosomes enhance wound healing in vitro and in vivo by promoting cell migration, collagen maturation, and angiogenesis.