Sleep and Wakefulness Research

This study identifies sleep-wake specific astrocytic Ca2+ signaling and its role in modulating sleep transitions and stability.

The paper measures neurochemical balance during sleep stages and finds NREM sleep increases plasticity for performance gains while REM sleep stabilizes learning post-training.

The paper shows astroglial calcium concentrations change with sleep and wake states, and mediate sleep need by affecting the homeostatic response to sleep deprivation.

The paper identifies a spontaneous sleep-like state in C. elegans induced by microfluidic confinement, regulated by satiety, thermosensation, and mechanosensation.

This paper introduces a phase discontinuity measure to assess sleep quality, finding increased phase discontinuity correlates with drowsiness, reduced deep sleep, and impaired REM sleep in older adults.

The paper introduces a method to measure sleep pressure and depth in Drosophila using movement data without disrupting behavior, showing these parameters are independent and influence total sleep.

This study shows orexin/hypocretin neurons rapidly control movement by integrating sensory input and initiating locomotion.

This paper identifies BOLD oscillations in fMRI that differentiate sleep from wake and correlate with spindles and slow waves.

The paper identifies 122 novel sleep-related genes from a large-scale knockout mouse study using non-invasive sleep monitoring.

This paper introduces a new classification of NREM sleep stages in mice, revealing human-like stages and their association with neuronal activity changes.

This paper introduces PiezoSleep, a noninvasive method to detect sleep/wake in narcoleptic mice, showing it can identify phenotypes and screen drugs efficiently.

This study identifies a basal ganglia circuit involving SNr and STN neurons that regulates sleep and motor control by modulating behavioral transitions.

This study characterizes electrophysiological properties and MCH/HO neuronal distribution in the lateral hypothalamus of naked mole-rats, finding similarities to mice but distinct distribution patterns.

This study finds that narcolepsy type 1 patients show increased brain activation to neutral-rated movies compared to controls, suggesting altered humor processing and potential links to cataplexy mechanisms.

This study identifies genetic risk loci for narcolepsy, showing enrichment in immune cells and suggesting autoimmune modulation via T cell receptor chains and influenza-A infection.

The paper investigates how pre-encoding alpha oscillations affect memory consolidation during wake versus sleep, finding that higher alpha power during wake enhances memory retention.

This study finds that orexin-deficient narcolepsy patients show enhanced ventral medial prefrontal cortex responses to food words, which predicts increased snack intake.

This study investigates whether memory reactivation during sleep remains effective in older adults, finding that while some benefit from targeted memory reactivation, others do not, with differences linked to sleep efficiency and oscillatory activity patterns.

This study shows that memory cues presented during slow oscillatory up-states during sleep improve recall, while cues during down-states do not.

The paper identifies neural activation patterns during sleep spindles correlated with reasoning abilities using EEG-fMRI.