Bacteriophages and microbial interactions

This study identifies DicC, a cryptic prophage transcription factor in E. coli, and shows it regulates hundreds of host genes, influencing bacterial phenotypes independently of other prophage genes.

This study examines how soil redox conditions influence viral communities and virus-host interactions in tropical rainforest soils, revealing distinct viral populations and their roles in carbon degradation.

This study shows that the archaeal CBASS system H-CBASS2 protects against both lytic and chronic viruses by depleting NAD+, with different kinetics depending on infection type.

The paper reanalyzes published metagenomic sequences of phage cocktails to identify temperate phages and bacterial DNA contamination, highlighting risks for horizontal gene transfer.

This paper develops a mathematical model showing that antibiotic-induced morphological changes in bacteria enhance phage predation and plaque size in structured environments.

The paper analyzes viral diversity in Lake Hazen, the largest High Arctic lake, using metagenomic and metatranscriptomic data to show unique evolutionary processes and high genetic diversity in High Arctic viruses.

The paper analyzes the gut mobilome in mother-infant dyads, finding increased infant mobilome richness over time, formula feeding effects, and antibiotic resistance gene presence in plasmids.

This study shows that OMVs and LPS from P. pseudoalcaligenes strain ERA inhibit Cystoviridae phages Phi 8 and Phi 12 infection, identifying LPS as the receptor and highlighting differences in LPS composition affecting binding.

The paper shows that Nucleocytoviricota viral factories are transient organelles formed by liquid-liquid phase separation, using scaffold proteins and client proteins.

The paper modifies the Appelmans protocol to evolve phages against Paenibacillus larvae, identifying new lysis patterns and improving phage diversity for honey bee pathogen treatment.

This study examines how selective breeding for tameness in mice affects gut virome diversity and identifies phage-host interactions linked to host behavior.

This study uses LPS-GUVs to demonstrate that bacteriophage DNA injection occurs via LPS-specific binding, without requiring OM proteins.

This study uses non-genetic mRNA silencing to identify essential genes in phage-host interactions, revealing new proteins critical for phage replication and host response.

This study integrates an artificial cyanophage genome into a cyanobacterium, identifies toxic genes, and shows altered metabolic pathways.

This study performs a comparative genomic analysis of 44 C. difficile phage genomes to classify them into nine clusters and propose new taxonomic categories.

This study investigates prophage-like elements in Bacillus subtilis across global and local scales, revealing their diversity, integration patterns, and potential impact on host evolution and physiology.

The paper identifies anti-phage defence systems encoded by sedentary chromosomal integron cassettes in Vibrio cholerae, showing 16 cassettes provide phage resistance.

This study reports four new marseillevirus strains, analyzes their biological properties, and predicts novel translation-associated proteins through in silico methods.

This paper introduces micro-plaque assays to improve phage isolation and characterization, showing they can isolate 21 unique phages from one sample and identify phage susceptibility in clinical strains.

The paper identifies and characterizes phage-plasmid hybrids across diverse environments, revealing their niche-specific functional traits and ecological roles.

The paper develops a computational pipeline to integrate antimicrobial payloads into bacteriophages by identifying optimal genomic loci using machine learning, validated experimentally with bioluminescent reporter genes.

The paper investigates the triadic interactions between gastric bacterial microbiome, phageome, and host genotype, finding that phages are influenced by both bacterial hosts and human genetic variants.

The paper uses interpretable machine learning to identify anti-defense genes in bacterial viruses, revealing their ability to counteract diverse bacterial immune systems.

This study investigates how gut phages transfer to the bloodstream and identifies immune factors that limit their persistence in circulation.

The paper analyzes 45 phage genomes to show a relationship between structural genes, GC content, and genome size, suggesting environmental adaptation influences phage evolution.

The paper studies the blood virome in healthy individuals and Crohn's disease patients, finding distinct viral communities associated with the disease.

The paper isolates and characterizes three lytic bacteriophages against multidrug-resistant K. pneumoniae, identifying receptor recognition modules and infection mechanisms.

This study shows engineered lysins can target and remodel synthetic human gut microbiomes by altering species preferences through domain recombination.

The paper identifies and characterizes novel metagenome-assembled virus genomes from the human gut, revealing new species and functional genes.

The paper describes a method for rapid phage-based pathogen detection using engineered internal capsid proteins that release a luciferase enzyme upon host presence.