Topic · Surgery · Medicine
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
37 papers
Jacob Croft, Liyuan Gao, Odalys Quintanar, Victor S. Sheng, Jun Zhang
This study identifies CCA subtype-specific biomarkers through bioinformatics analysis of transcriptomic data and machine learning prediction of transcription factors.
bioRxiv · Aug 21, 2023 · PreprintSystems Biology
Xinyi Zhou, Tengda Huang, Hongyuan Pan, Jiang Lan, Tian Wu, Ao Du, Yujia Song, Yue Lv, Kefei Yuan
This study uses bioinformatics to identify shared differentially expressed genes between SARS-CoV-2 infection and intrahepatic cholangiocarcinoma, revealing potential therapeutic targets.
bioRxiv · Jan 4, 2023 · PreprintBioinformatics
Min-Su Kang, Hee Young Na, Soomin Ahn, Ji-Won Kim, Ju Hyun Lee, 안소연, Jeonghwan Youk, Haesook T. Kim, Se Hyun Kim, Koung Jin Suh, J Y Lee, Jin Won Kim, Yu Jung Kim, Keun‐Wook Lee, Jong Seok Lee, , Ho‐Seong Han
This study traces the evolutionary paths of gallbladder adenocarcinomas, showing subclonal diversification and selection from precancerous lesions to metastatic tumors.
eLife · Dec 8, 2022Peer-reviewedGenetics
Nabanita Roy, Mrinmoy Kshattry, Susmita Mandal, Mohit Kumar Jolly, Dhruba K. Bhattacharyya, Pankaj Barah
This study identifies key genes and transcription factors linked to gallbladder cancer pathogenesis using integrative systems biology approaches and transcriptomic data analysis.
Journal of Clinical Medicine · Aug 10, 2021Peer-reviewedSystems Biology
Prissadee Thanaphongdecha, Shannon E. Karinshak, Wannaporn Ittiprasert, Victoria H. Mann, Yaovalux Chamgramol, Chawalit Pairojkul, James G. Fox, Sutas Suttiprapa, Banchob Sripa, Paul J. Brindley
The paper shows that CagA+ Helicobacter pylori infection induces epithelial to mesenchymal transition in human cholangiocytes, promoting migration, invasion, and colony formation.
Pathogens · Nov 21, 2020Peer-reviewedMolecular Biology
Patpicha Arunsan, Apisit Chaidee, Christina J. Cochran, Victoria H. Mann, Toshihiko Tanno, Chutima Kumkhaek, Michael J. Smout, Shannon E. Karinshak, Rutchanee Rodpai, Javier Sotillo, Alex C. Loukas, Thewarach Laha, Paul J. Brindley, Wannaporn Ittiprasert
The paper investigates how liver fluke granulin promotes exosome-mediated crosstalk that alters the cellular microenvironment to support cholangiocarcinoma development.
Neoplasia · Mar 31, 2020Peer-reviewedMolecular Biology
Stephanie Greer, Margret Helga Ogmundsdottir, Jiamin Chen, Billy T. Lau, Richard Glenn C. Delacruz, Imelda T. Sandoval, Sigrún Kristjánsdóttir, David A. Jones, Derrick S. Haslem, Robin Romero, Gail Fulde, John Bell, Jon Gunnlaugur Jonasson, Eirı́kur Steingrı́msson, Hanlee P. Ji, Lincoln D. Nadauld
The paper identifies ATG7 as a genetic risk factor for cholangiocarcinoma through germline mutations and population studies, linking autophagy dysfunction to cancer development.
bioRxiv · Nov 22, 2019 · PreprintGenomics