Reproductive System and Pregnancy

Derivation of endometrial gland organoids from term post-partum placenta

This study establishes endometrial gland organoids from term placental decidua and identifies survival factors for co-culture with stromal fibroblasts, enabling patient-specific models with known pregnancy outcomes.

The maternal-fetal interface of successful pregnancies and impact of fetal sex using single cell sequencing

The paper uses single-cell RNA sequencing to analyze maternal-fetal interface cell types and identifies sex-specific differences in immune cell function and regulatory pathways.

The genetic architecture of sporadic and recurrent miscarriage

This study identifies genetic variants associated with sporadic and recurrent miscarriage through large-scale association analyses and Mendelian randomization.

Towards a Gamete Matching Platform: Using Immunogenetics and Artificial Intelligence to Predict Recurrent Miscarriage

The paper develops an algorithm to predict recurrent miscarriage using HLA haplotypes and immunogenetics, achieving an AUC of 0.71.

HMGB1 orchestrates uterine macrophage trafficking to safeguard embryo implantation

This study shows HMGB1 in the uterus restricts inflammation by controlling macrophage trafficking, which is essential for successful embryo implantation.

Reconstructing the human first trimester fetal-maternal interface using single cell transcriptomics

The paper profiles single-cell transcriptomes from the human first trimester fetal-maternal interface, revealing cellular composition and interactions critical for placentation.

Pulse of α-2-macroglobulin and lipocalin-1 in the pregnant uterus of European polecats (Mustela putorius) at the time of implantation

The paper identifies changes in uterine secretory proteins in European polecats during implantation, highlighting increased α-2-macroglobulin and lipocalin-1.